◀ Back to RELA
RELA — SOD3
Text-mined interactions from Literome
Shi et al., Mol Cell Biochem 1999
:
This activation of
NF-kappaB was decreased by a metal chelator, diethylene triaminepentaacetic acid or a H2O2 scavenger, catalase, but was
increased by
superoxide dismutase
Wang et al., Ann Clin Lab Sci 1999
:
Superoxide dismutase ( SOD ) , but not catalase or sodium formate,
inhibited this
NF-kappaB activation, suggesting that O2*- rather than H2O2 or *OH, radicals play the most critical role in this induction
Darville et al., Endocrinology 2000
:
NF-kappaB is
required for cytokine induced manganese
superoxide dismutase expression in insulin producing cells
Ye et al., Ann Clin Lab Sci 2000
:
Exogenous
superoxide dismutase ( SOD ) enhanced the
NF-kappaB activation by PMA, while catalase blocked it
Jan et al., J Virol 2000
(Neuroblastoma) :
The finding that AACOCF ( 3 ) and
SOD significantly
block activation of
NF-kappaB suggests that this activation is derived from the AA-superoxide anion pathway
Kim et al., J Korean Med Sci 2000
(Acute Disease...) :
Present study aims to investigate whether neutrophils primed by 4beta-phorbol 12beta-myristate 13alpha-acetate ( PMA ) affect the productions of H2O2 and lipid peroxide (LPO),
NF-kappaB activation and cytokine production in pancreatic acinar cells, and whether these alterations were
inhibited by N-acetylcysteine (NAC) and
superoxide dismutase ( SOD )
Seo et al., Pharmacology 2002
:
Small-molecule antioxidants and
SOD inhibited
NF-kappaB activation and cytokine production in acinar cells caused by PMA primed neutrophils
Fan et al., J Biol Chem 2003
(Anoxia) :
Overexpression of glutathione peroxidase-1 or catalase, but not
Mn-SOD or Cu, Zn-SOD, significantly
reduced both
NF kappa B activation and tyrosine phosphorylation of I kappa B alpha
Casciati et al., J Neurochem 2002
(Amyotrophic Lateral Sclerosis...) :
In this paper, we report a calcineurin dependent activation of
nuclear factor-kappaB (NF-kappaB) induced by the expression of familial amyotrophic lateral sclerosis ( fALS )
-SOD1s in human neuroblastoma cell lines
Yang et al., Mol Ther 2003
(Myocardial Reperfusion Injury...) :
These findings support the notion that both mitochondrial and cytoplasmic derived
SOD induce changes in AP-1 and
NF kappa B activity, creating an antiapoptotic microenvironment within cardiomyocytes that affords protection following I/R injury
Cardoso et al., Free radical research 2003
(Alzheimer Disease) :
We observed that the
NF-kB inhibitor, PDTC,
prevented SOD overexpression after A beta treatment
Kaneko et al., Biol Pharm Bull 2004
:
Manganese
superoxide dismutase is
induced by endoplasmic reticulum stress through IRE1 mediated
nuclear factor (NF)-kappaB and AP-1 activation
Yune et al., J Neurotrauma 2004
(Spinal Cord Injuries) :
Manganese
superoxide dismutase induced by TNF-beta is
regulated transcriptionally by
NF-kappaB after spinal cord injury in rats
Song et al., J Cereb Blood Flow Metab 2005
(Brain Ischemia) :
However,
SOD 1
prevented NF-kappaB activation, and phosphorylation and degradation of IkappaBalpha after tFCI
Rui et al., FASEB J 2005
(Inflammation) :
NFkappaB and AP-1 differentially
contribute to the induction of
Mn-SOD and eNOS during the development of oxidant tolerance ... In this model, nuclear translocation of both
NF-kappaB and AP-1 is
required for induction of
Mn-SOD , while nuclear translocation of AP-1, but not NF-kappaB, is a prerequisite for induction of eNOS
Gomez-Cabrera et al., Br J Nutr 2006
:
In animal models, we previously showed that
NF-kappaB activation induced by exhaustive physical exercise
leads to an increase in the expression of
superoxide dismutase , an enzyme involved in antioxidant defence
Yang et al., Chin J Integr Med 2007
(Learning Disorders...) :
TCA could improve A beta 25-35 induced dysfunction of learning and memory in rats, and its protective mechanism is associated with its actions in decreasing MDA level, increasing
Mn-SOD activity and
inhibiting the expression of
NF-kappa B in cerebral cortex
ViƱa et al., Biol Chem 2008
:
Activation of
NF-kappa B by estrogens subsequently
activates the expression of
Mn-SOD and GPx, but genistein is only capable of activating Mn-SOD expression
Kiningham et al., Free Radic Biol Med 2008
(Neuroblastoma) :
All-trans-retinoic acid
induces manganese
superoxide dismutase in human neuroblastoma through
NF-kappaB
Xu et al., Planta Med 2008
(Infarction, Middle Cerebral Artery...) :
Pre-treatment with isosteviol reduced infarct volume, ameliorated cell death and infiltration of neutrocytes, improved neuro-locomotor activity, increased
SOD activity, induced Bcl-2,
suppressed lipid superoxidation and the expression of
NF-kappaB , and therefore retarded necrosis and apoptosis of neurons and inflammation
Zhang et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2008
(Disease Models, Animal) :
Compared with control group,
SOD activity in LPS group decreased at different time points significantly ( P < 0.05 or P < 0.01 ), but MPO activity, MDA content and the expression of
NF-kappaB increased obviously ( P < 0.05 or P < 0.01 ) ; the administration of MT and DEX could mitigate above values significantly ( P < 0.05 or P < 0.01 )
Lee et al., Exp Mol Med 2009
:
Tat-SOD inhibited LPS induced
NF-kappaB DNA binding activity, IkappaBalpha degradation and activation of MAP kinases
Shan et al., J Biomed Biotechnol 2009
(Brain Injuries...) :
Interestingly, we found, PSPC decreased the expression level of glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2),
inhibited nuclear translocation of nuclear factor-kappaB
(NF-kappaB) , increased the activity of copper/zinc
superoxide dismutase ( Cu/Zn-SOD ) and catalase (CAT), and reduced the content of malondialdehyde ( MDA ), respectively
Lee et al., Mol Cells 2010
(MAP Kinase Signaling System) :
Furthermore, cell-permeable
SOD inhibited LPS induced
NF-kappaB DNA binding activity and activation of MAP kinases including ERK, JNK, and p38 in BV-2 cells
Das et al., Mol Cell Biochem 1995
(Adenocarcinoma...) :
TNF alpha and IL-1 each can activate
NF-kappa B and
induce gene expression of manganese
superoxide dismutase ( MnSOD ), a mitochondrial matrix enzyme which can provide critical protection against hyperoxic lung injury
Weiss et al., J Immunol 1997
:
TNFR80 induces no cytotoxicity on its own, but is functional in these transfectants, as selective stimulation activates
nuclear factor-kappaB (NF-kappaB) and
induces NF-kappaB dependent cellular responses ( IL-6 and manganese
superoxide dismutase )
Marumo et al., Circulation 1997
:
In contrast,
superoxide dismutase did not
inhibit the interleukin-1beta induced
NF-kappaB activation
Schmidt et al., Chem Biol 1995
(Second Messenger Systems) :
In contrast, stable overexpression of cytoplasmic Cu/Zn dependent
superoxide dismutase ( SOD ) , which enhances the production of H2O2 from superoxide,
potentiated NF-kappa B activation
Borrello et al., Arch Biochem Biophys 1997
:
NF kappa B-independent transcriptional
induction of the human manganous
superoxide dismutase gene
Manna et al., J Biol Chem 1998
:
Besides TNF, phorbol ester-, okadaic acid-, ceramide-, and lipopolysaccharide induced activation of
NF-kappaB was
blocked by
Mn-SOD , indicating a common pathway of activation