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CDKN2A — S100A4

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Kai et al., Jpn J Cancer Res 1995 (Urinary Bladder Neoplasms) : We examined a candidate tumor suppressor gene on chromosome 9p21, MTS1/CDK4I ( multiple tumor suppressor 1/cyclin dependent kinase 4 inhibitor ), which has been found to be mutated frequently in cell lines derived from bladder carcinomas, for somatic mutations in 39 primary bladder cancers by means of SSCP ( single stranded conformational polymorphism ) and DNA sequencing
Mori et al., Cancer Res 1994 (Carcinoma, Squamous Cell...) : Since recently published studies have shown that a gene mapped on chromosome 9p21, MTS1/CDK4I ( multiple tumor suppressor 1/cyclin dependent kinase 4 inhibitor ), is frequently mutated in various types of tumors, we chose to examine esophageal squamous cell carcinomas for mutations in this candidate gene