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IL8 — MMP9

Text-mined interactions from Literome

Pruijt et al., Curr Opin Hematol 1999 : Additional experiments showed that interleukin-8 induces the rapid release of the metalloproteinase gelatinase B , concurrent with the mobilization of hematopoietic progenitor cells ... Because neutrophils express leukocyte function associated antigen-1 and high affinity interleukin-8 receptors, and release gelatinase B upon stimulation with interleukin-8 , we hypothesized that neutrophils are key mediators in interleukin-8 induced stem cell mobilization
Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Pruijt et al., Proc Natl Acad Sci U S A 1999 : Because activation of neutrophils by IL-8 induces the release of gelatinase B ( MMP-9 ), which is involved in the degradation of extracellular matrix molecules, we hypothesized that MMP-9 release might induce stem cell mobilization by cleaving matrix molecules to which stem cells are attached ... Preinjection of inhibitory antibodies did not preclude the IL-8 induced production and secretion of MMP-9 ... In summary, IL-8 induces the rapid systemic release of MMP-9 with concurrent mobilization of HPC that is prevented by pretreatment with an inhibitory anti-gelatinase B antibody, indicating that MMP-9 is involved as a mediator of the IL-8 induced mobilization of HPC
Kido et al., Eur J Cancer 2001 (Disease Progression...) : More recently, we found that IL-8 upregulates matrix metalloproteinase-9 (MMP-9) expression and increases invasive activity of gastric carcinoma cells
Shibakura et al., Br J Haematol 2002 (Leukemia, Myeloid) : However, recombinant IL-8 did not induce MMP-9 expression ... These observations suggest that ATRA can induce both MMP-9 and IL-8, but IL-8 is not involved in ATRA induced MMP-9 expression
Watanabe et al., Oral Oncol 2002 (Carcinoma, Squamous Cell...) : Second, we thus also investigated the effect of IL-8 on MMP release in OSCC cells
Mian et al., Clin Cancer Res 2003 (Carcinoma, Transitional Cell...) : IL-8 blockade by ABX-IL8 significantly inhibited the expression, activity, and transcription of MMP-2 and MMP-9 , resulting in decreased invasion through reconstituted basement membrane in vitro
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Mulayim et al., Fertil Steril 2004 : To evaluate the effect of interleukin-8 (IL-8) on endometrial stromal cell metalloproteinase ( MMP ) activity and invasiveness ... IL-8 increases MMP activity and invasive capability of endometrial stromal cells in culture ; IL-8 may be involved in the pathogenesis of endometriosis and menstrual physiology
So et al., Gynecol Oncol 2004 (Neoplasm Invasiveness...) : IL-8 did not affect cellular migration, MMP2 activation, or uPA expression
Chakrabarti et al., J Leukoc Biol 2005 (MAP Kinase Signaling System) : We examined the signaling mechanisms that regulate interleukin-8 (IL-8) mediated MMP-9 release from neutrophils ... Blocking CXCR1 had no effect on IL-8 mediated MMP-9 release, whereas blocking CXCR2 significantly reduced MMP-9 release ... Src-family kinases and protein kinase C ( PKC ) were involved in two mutually exclusive pathways regulating IL-8 mediated MMP-9 release ... Inhibition of extracellular signal regulated kinase ( ERK ) 1/2 blocked IL-8 mediated MMP-9 release ; however, inhibition of p38 mitogen activated protein kinase had no effect on MMP-9 release ... These data suggest that IL-8 induced MMP-9 release from neutrophils is mediated through CXCR2 and involves two distinct pathways, one involving PKC and ERK1/2 and the other involving Src-family kinases
Giannelli et al., J Interferon Cytokine Res 2006 : In this study, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), commonly elevated in chronic C hepatitis, stimulate the production of matrix metalloprotease-9 (MMP-9) by human hepatocytes at a transcriptional and translational level, but the addition of recombinant interferon-alpha2b ( rIFN-alpha2b ) hampers this effect
Thirumangalakudi et al., J Alzheimers Dis 2007 : Gelatin zymography demonstrated IL-8 induced MMP-2 and MMP-9 activity
Hanrahan et al., J Clin Oncol 2010 (Lung Neoplasms) : For example, increases in IL-8 with VCP, MMP-9 with CP, and VEGF with vandetanib monotherapy were associated with increased progression risk, and increase in intercellular adhesion molecule 1 with vandetanib was associated with decreased risk
Jovanović et al., Reproduction 2010 : Exogenous IL8/CXCL8 increased trophoblast cell migration and invasion, which may be partly attributable to stimulation of MMP2 and MMP9 levels and an increase in integrins
Tanabe et al., Molecules (Basel, Switzerland) 2011 : This concentration of AC-PACs also significantly increased the secretion of IL-8 ( 6-fold ) and inhibited the secretion of both MMP-2 and MMP-9
Jönsson et al., PloS one 2011 (Angina Pectoris) : Upon moderate stimulation with IL-8 , the neutrophil release of MMP-9 was higher in the SA patients compared with controls ( p < 0.05 )
Müller-Edenborn et al., Anesthesiology 2012 (Colorectal Neoplasms...) : Preconditioning reduced interleukin-8 induced MMP-9-release by 41 % ( ±13, 5 %, sevoflurane ) and 40 % ( ±13 %, desflurane )
Thirkettle et al., J Biol Chem 2013 (Breast Neoplasms) : In particular, MMP-8 proteolytically activates IL-8 and, thereby, regulates neutrophil chemotaxis in vivo
Alexander et al., Curr Eye Res 1998 : A phorbol mitogen ( TPA ), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B , stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression ; TIMP-2 levels are reduced by TNF but not affected by the other treatments