◀ Back to MAPK14
ALOX5 — MAPK14
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
ALOX5
→
MAPK14
(increases, MAPK14 Activity, ALOX5 Activity)
Werz et al., Proc Natl Acad Sci U S A 2000*
Evidence: Different agents activated the 5-LO kinase activities, including stimuli for cellular leukotriene biosynthesis (A23187, thapsigargin, N-formyl-leucyl-phenylalanine), compounds that up-regulate the capacity for leukotriene biosynthesis (phorbol 12-myristate 13-acetate, tumor necrosis factor alpha, granulocyte/macrophage colony-stimulating factor), and well known p38 stimuli as sodium arsenite and sorbitol. For all stimuli, 5-LO kinase activation was counteracted by SB203580 (3 microM or less), an...
Text-mined interactions from Literome
Werz et al., Blood 2002
:
In contrast, stress induced product formation and translocation of
5-LO , as well as
activation of p38
MAPK , occurred also after Ca ( ++ ) depletion
Ha et al., Exp Mol Med 2011
:
We describe an alternative ROS production pathway that is triggered by CD40 ligation,
involves 5-lipoxygenase (5-LO) , and results in activation of p38
MAPK