◀ Back to PML
PML — SUMO1
Pathways - manually collected, often from reviews:
-
BioCarta regulation of transcriptional activity by pml:
p53 (TP53)
→
PML/sp100/SUMO1/p53 complex (PML-SP100-TP53-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
p53 (TP53)
→
PML/sp100/SUMO1 complex (PML-SP100-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/sp100/SUMO1/p53 complex (PML-SP100-TP53-SUMO1)
→
PML/sp100/SUMO1 complex (PML-SP100-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
p53 (TP53)
→
PML/sp100/SUMO1 complex (PML-SP100-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
p53 (TP53)
→
PML/sp100/SUMO1/p53(+1) complex (PML-SP100-TP53-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/sp100/SUMO1 complex (PML-SP100-SUMO1)
→
PML/sp100/SUMO1/p53(+1) complex (PML-SP100-TP53-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/SUMO1 complex (PML-SUMO1)
→
PML
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/SUMO1 complex (PML-SUMO1)
→
Ubc9 (UBE2I)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/SUMO1 complex (PML-SUMO1)
→
SUMO1/Ubc9 complex (UBE2I-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML
→
SUMO1/Ubc9 complex (UBE2I-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/sp100/SUMO1/p53 complex (PML-SP100-TP53-SUMO1)
→
histone transacetylase (CREBBP)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/sp100/SUMO1/p53 complex (PML-SP100-TP53-SUMO1)
→
PML/sp100/SUMO1/p53(+1) complex (PML-SP100-TP53-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
histone transacetylase (CREBBP)
→
PML/sp100/SUMO1/p53(+1) complex (PML-SP100-TP53-SUMO1)
(modification, activates)
-
BioCarta regulation of transcriptional activity by pml:
sp100 (SP100)
→
PML/SUMO1 complex (PML-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
sp100 (SP100)
→
PML/sp100/SUMO1 complex (PML-SP100-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/SUMO1 complex (PML-SUMO1)
→
PML-RAR (PRAM1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML/SUMO1 complex (PML-SUMO1)
→
PML/sp100/SUMO1 complex (PML-SP100-SUMO1)
(modification, collaborate)
-
BioCarta regulation of transcriptional activity by pml:
PML-RAR (PRAM1)
→
PML/sp100/SUMO1 complex (PML-SP100-SUMO1)
(modification, inhibits)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
SUMO1
—
PML
(two hybrid)
Lin et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Rabellino et al., Cancer Res 2012*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, enzymatic study)
Lin et al., Mol Cell 2006*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Lin et al., Mol Cell 2006*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, fluorescent resonance energy transfer)
Percherancier et al., J Biol Chem 2009*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Percherancier et al., J Biol Chem 2009*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, two hybrid)
Cuchet-Lourenço et al., J Virol 2012*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Satow et al., Gastroenterology 2012*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, pull down)
Satow et al., Gastroenterology 2012*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(colocalization, imaging technique)
Ohbayashi et al., Biochem Biophys Res Commun 2008*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Sarkari et al., PloS one 2011*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Adamson et al., J Virol 2001*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Quimby et al., Oncogene 2006*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, two hybrid)
Stehmeier et al., Mol Cell 2009*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, two hybrid)
Duprez et al., J Cell Sci 1999*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Shen et al., Mol Cell 2006*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, pull down)
Shen et al., Mol Cell 2006*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
El McHichi et al., J Virol 2010*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Renner et al., Mol Cell 2010*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Kunapuli et al., Exp Cell Res 2006*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Gresko et al., Oncogene 2009*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, enzymatic study)
Gocke et al., J Biol Chem 2005
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Fukuyo et al., Cell Death Differ 2004*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, fluorescent resonance energy transfer)
Maroui et al., PloS one 2012*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Yang et al., EMBO J 2006*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Da Silva-Ferrada et al., Scientific reports 2013*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(direct interaction, two hybrid)
Lin et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Kamitani et al., J Biol Chem 1998*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Gao et al., Mol Cell Biol 2008*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Saether et al., J Biol Chem 2007*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Cuchet-Lourenço et al., PLoS Pathog 2011*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(colocalization, imaging technique)
Cuchet-Lourenço et al., PLoS Pathog 2011*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Chu et al., Oncogene 2011*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Li et al., Oncogene 2011*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Müller et al., EMBO J 1998*
-
IRef Biogrid Interaction:
SUMO1
—
PML
(physical association, affinity chromatography technology)
Galisson et al., Mol Cell Proteomics 2011
-
IRef Hprd Interaction:
PML
—
SUMO1
(in vitro)
Fogal et al., EMBO J 2000*, Lin et al., J Biol Chem 2002*, Boddy et al., Oncogene 1996*, Kamitani et al., J Biol Chem 1998*
-
IRef Hprd Interaction:
PML
—
SUMO1
(in vivo)
Fogal et al., EMBO J 2000*, Lin et al., J Biol Chem 2002*, Boddy et al., Oncogene 1996*, Kamitani et al., J Biol Chem 1998*
-
IRef Intact Interaction:
PML
—
SUMO1
(physical association, two hybrid)
Lin et al., J Biol Chem 2002*
-
IRef Intact Interaction:
PML
—
SUMO1
(physical association, anti tag coimmunoprecipitation)
Yang et al., EMBO J 2006*
-
IRef Intact Interaction:
PML
—
SUMO1
(physical association, anti bait coimmunoprecipitation)
Li et al., Oncogene 2011*
-
IRef Ophid Interaction:
PML
—
SUMO1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Häkli et al., Exp Cell Res 2005
:
Ectopic expression of
SUMO-1 markedly
enhances the interaction between
PML3 ( PML IV ) and SNURF, but covalent attachment of SUMO-1 to neither protein is required
Mukhopadhyay et al., Mol Cell 2011
:
In this issue, Chang et al. ( 2011 ) provide structural insights into how phosphorylation of Daxx increases its affinity toward SUMOs and functional insights into how enhanced
SUMO binding
affects Daxx-PML interactions, PML nuclear body localization, and Daxx mediated repression of genes encoding for antiapoptotic factors