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AKT1 — SMAD4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
PI3K/Akt dependent transcriptional regulation and activation of
BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells
Sweetwyne et al., Am J Pathol 2010
:
Collagen stimulation was independent of TGF-ß activity and
Smad phosphorylation but was
blocked by an
Akt inhibitor, suggesting that signaling through the Akt pathway is important for regulation of collagen through TSP1 binding to calreticulin
Han et al., Int J Biochem Cell Biol 2013
:
In addition,
Smad activation inhibits muscle protein synthesis by
suppressing Akt signaling