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SRC — TGFB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Park et al., Cell Growth Differ 2001
:
Mechanism of
induction of
transforming growth factor-beta type II receptor gene expression by
v-Src in murine myeloid cells
Koseki et al., Cell Signal 2002
:
TGF-beta1 and activin A
caused the growth suppression and concomitant expression of tartrate-resistant acid phosphatase ( TRAP ) and
c-Src , without inducing syncytium formation or increasing the survival rate in RAW264.7 cells
Kim et al., J Biol Chem 2002
:
TGF-beta 1 also
stimulated Src kinase activity, and specific inhibitors of Src completely blocked the induction of Cas phosphorylation by TGF-beta 1
Zheng et al., J Biol Chem 2002
:
These findings suggest that
TGF-beta1 regulates HEF1 gene expression and that HEF1 phosphorylation is
dependent on cell adhesion and
Src kinase activity
Park et al., Oncogene 2004
:
TGF-beta1 induced transient activation of
c-Src and its subsequent caspase mediated degradation concomitant with cell death in FaO hepatoma cells, which are sensitive to TGF-beta1
Sato et al., Arterioscler Thromb Vasc Biol 2005
:
Our results suggest that
TGF-beta1 activates
c-Src and generates hydrogen peroxide through NAD ( P ) H oxidase, and these signaling pathways lead to the activation of specific sets of genes, including SM22alpha and PAI-1 ... These results indicate that
c-Src and hydrogen peroxide are
required for
TGF-beta1 signaling
Murillo et al., Oncogene 2005
:
The
activation of
c-Src by
TGF-beta1 is EGFR dependent and is required for full Akt phosphorylation and cell survival
Inagaki et al., J Biol Chem 2005
:
Here, we show that 1 ) KTI suppressed
TGF-beta1 induced phosphorylation of
Src , ERK1/2, and Akt by 40-60 % ; 2 ) KTI was insensitive to suppress the phosphorylation of ERK1/2 and Akt in the constitutively active ( CA ) -c-Src ( Y529F ) cells ; 3 ) uPA expression was up-regulated in TGF-beta1 stimulated HRA cells and in unstimulated Y529F cells ; 4 ) the addition of KTI reduced the TGF-beta1 induced increase of uPA gene and protein expression in the wild-type c-Src transfected cells ( in contrast, KTI could not inhibit uPA expression in the Y529F cells ) ; and 5 ) CA-c-Src transfection resulted in a 2-fold increase in invasiveness, whereas KTI did not reduce invasion of the Y529F cells
Maeda et al., J Biol Chem 2006
:
Src activation is not
necessary for
transforming growth factor ( TGF ) -beta mediated epithelial to mesenchymal transitions ( EMT ) in mammary epithelial cells
Lee et al., Am J Respir Cell Mol Biol 2007
:
Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion
kinase/Src
Peng et al., American journal of physiology. Renal physiology 2008
:
TGFbeta1 also
activated Src , and its inhibition blocked RhoA activation
Shi-wen et al., Arthritis Rheum 2009
(Fibrosis) :
Some fibrogenic transcriptional responses to
transforming growth factor beta ( TGFbeta ), including alpha-smooth muscle actin ( alpha-SMA ) expression and ECM contraction,
require focal adhesion kinase/Src (FAK/Src)
Zhang et al., J Cell Physiol 2010
:
In this study we demonstrate that
TGF-beta1 activates Src kinase in ROS17/2.8 cells and that treatment with the Src family kinase inhibitor PP2
prevents Src activation and CTGF induction by TGF-beta1
Xie et al., Cell communication and signaling : CCS 2013
:
Furthermore, overexpression of Cx43 or inhibition of
c-Src attenuated the upregulation of intercellular adhesion molecule-1 ( ICAM-1 ),
transforming growth factor-beta 1 ( TGF-ß1 ) and fibronectin ( FN ) expression induced by high glucose
Fukuda et al., Oncogene 1998
:
To determine whether Src kinase is also involved in TGF-beta signaling, we examined the
effects of
TGF-beta1 on
Src in the rat fibroblast cell line 3Y1 and in v-Src transformed 3Y0 ( SR-3Y1 )
Fukuda et al., Hepatology 1998
(Carcinoma, Hepatocellular...) :
TGF-beta1 decreased Src kinase activity in HepG2 cells, but
increased cellular
Src levels and Src kinase activity in Mahlavu cells