Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Sun et al., Toxicol Appl Pharmacol 2006 : However, TNT mediated phosphorylation of either eNOS or Akt was drastically blocked by NAC and PEG-CAT
Chen et al., Diabetes 2006 : Antioxidant N-acetyl-l-cysteine (NAC) prevented mercury induced insulin secretion inhibition and Akt phosphorylation but not increased PI3K activity
Choi et al., Oxidative medicine and cellular longevity 2010 : Akt was slowly phosphorylated after treatment with DA, while NAC clearly inhibited the DA-induced Akt activation
Yang et al., PloS one 2013 : The AGEs stimulated Akt activation was blocked by a PI3-kinase inhibitor LY 294002, Src inhibitor PP2, an antioxidant NAC , superoxide scavenger Tiron, or nicotinamide adenine dinucleotide phosphate ( NAD ( P ) H ) oxidase inhibitor DPI, suggesting the involvement of Src and NAD ( P ) H oxidase in the activation of PI3-kinase-Akt pathway by AGEs
Owada et al., PloS one 2013 : N-acetylcysteine (NAC) , an antioxidant reagent, reduced both the increase in cellular H2O2 levels and AKT phosphorylation induced by glucose deprivation
Pramanik et al., Carcinogenesis 2013 (Melanoma...) : Our results indicate that NAC blocked CAPE mediated AKT/XIAP inhibition and protected the cells from apoptosis