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CTNND1 — WNT16

Text-mined interactions from Literome

Park et al., Dev Cell 2006 : Despite recent advances in understanding the roles that p120-catenin and Kaiso play in downstream modulation of Wnt/beta-catenin signaling, the identity of the upstream regulators of the p120-catenin/Kaiso pathway have remained unclear ... In Xenopus laevis, we demonstrate that Wnt signals result in Frodo mediated stabilization of p120-catenin , which, in turn, promotes Kaiso sequestration or removal from the nucleus ... Importantly, this suggests that Wnt signals acting through Dsh regulate the stability of p120-catenin in addition to that of beta-catenin, and that each catenin promotes its respective signal in parallel to regulate distinct, as well as shared, direct downstream gene targets
Casagolda et al., J Cell Sci 2010 : A p120-catenin-CK1epsilon complex regulates Wnt signaling ... We describe here that p120-catenin is required for Wnt pathway signaling
Hong et al., J Cell Sci 2010 : Again in parallel with ß-catenin, reduction of canonical Wnt signals upon depletion of LRP5 and LRP6 results in p120-catenin degradation
Del Valle-Pérez et al., J Cell Sci 2011 : Here, we describe that Wnt induced p120-catenin phosphorylation at Ser268 and Ser269 also enhances its binding to the transcriptional factor Kaiso, preventing Kaiso mediated inhibition of the ß-catenin-Tcf-4 transcriptional complex