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AKT3 — SREBF1

Text-mined interactions from Literome

Ono et al., Diabetes 2003 (Fatty Liver...) : In contrast, myr-Akt induced hypertriglyceridemia and hepatic triglyceride accumulation are mediated by both Akt induced SREBP-1 expression and a mechanism involving fatty acid synthesis independent of SREBP-1
Porstmann et al., Oncogene 2005 : Activation of Akt induces synthesis of full-length SREBP-1 and SREBP-2 proteins as well as expression of fatty acid synthase (FAS), the key regulatory enzyme in lipid biosynthesis ... We also show that Akt leads to the accumulation of nuclear SREBP-1 but not SREBP-2, and that activation of SREBP is required for Akt induced activation of the FAS promoter
Rudolph et al., J Mammary Gland Biol Neoplasia 2007 : Stability of SREBP1 may be enhanced by a significant increase in Akt at secretory activation
Yellaturu et al., J Biol Chem 2009 : Furthermore, chemical and molecular inhibitors of the phosphoinositide 3-kinase pathway and its downstream kinase protein kinase B (PKB)/Akt prevented both insulin mediated phosphorylation of nascent SREBP-1c protein and its posttranslational processing
Lewis et al., Adv Enzyme Regul 2011 : It has been shown that nuclear accumulation of the mature form of SREBP1 is induced in response to activation of the serine/threonine kinase Akt , an important effector of the Ras/PI3-kinase signalling pathway
Yecies et al., Cell Metab 2011 : Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1 dependent and independent pathways