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COL2A1 — SP1

Text-mined interactions from Literome

Chadjichristos et al., J Biol Chem 2002 : These findings suggest that TGF-beta1 inhibition of COL2A1 gene transcription in RAC is mediated by an increase of the Sp3/Sp1 ratio and by the repression of Sp1 transactivating effects on that gene
Chadjichristos et al., J Biol Chem 2003 : Because we demonstrated previously that Sp1 was a strong activator of COL2A1 gene expression via the -63/+1 promoter region, whereas Sp3 overexpression blocked Sp1 induced promoter activity and inhibited COL2A1 gene transcription, we conclude that IL-1 beta down-regulation of that gene, as we found previously for transforming growth factor-beta 1, is mediated by an increase in the Sp3/Sp1 ratio
Porée et al., J Biol Chem 2008 (Osteoarthritis) : Indeed, overexpression of a full-length Sp3 cDNA blocked the Sp1 up-regulation of the 63-bp COL2A1 promoter activity, and by itself, inhibits COL2A1 transcription
Renard et al., J Mol Med (Berl) 2012 : These data demonstrate the role of Sox9, Sp1/Sp3 , and euchromatin associated factors ( p300, Tip60 ) in the IGF-I induced upregulation of COL2A1 , indicating possible use of this growth factor in articular cartilage engineering applications to promote repair in patients with degenerative diseases, such as osteoarthritis ... These data demonstrate the role of Sox9, Sp1/Sp3 , and euchromatin associated factors ( p300, Tip60 ) in the IGF-I induced upregulation of COL2A1 , indicating possible use of this growth factor in articular cartilage engineering applications to promote repair in patients with degenerative diseases, such as osteoarthritis