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IL12RB1 — IL2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Wu et al., Eur J Immunol 2000
:
Using an antibody specific for the human IL-12Rbeta2 subunit, the
effect of IFN-gamma, IFN-alpha, IL-12 and
IL-2 on the regulation of
IL-12R expression and IL-12 responsiveness of human T and NK cells was assessed
Elloso et al., Eur J Immunol 2001
:
IL-2 could
restore IL-12R expression to CD28 ( -/- ) CD4 ( + ) cells, however, this occurred independently of IL-2 induced proliferation
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA,
IL-12R , IL-2Ralpha and CD40L expression and also
inhibited IL-12- and IL-23 induced IFN-gamma, IL-17A, tumor necrosis factor (TNF)-alpha,
IL-2 , and IL-10 secretion
Wu et al., Eur J Immunol 1997
:
Among 16 cytokines tested,
IL-2 , IL-7 and IL-15 markedly
induced IL-12Rbeta1 expression and IL-12 binding on resting PBMC, whereas IL-1alpha and tumor necrosis factor-alpha had a minimal enhancing effect
Fujimiya et al., Clin Cancer Res 1997
(Brain Neoplasms...) :
Thus, the increased expression of the IL-2Rbeta is critical for the synergistic activation of gammadelta T cells by IL-12 plus IL-2 ; it is also probable that at least the low-affinity
IL-12R contributes to the activation of gammadelta T cells mediated by either IL-12 alone or IL-12 plus
IL-2