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CDC20 — CDKN1A

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDC20 — CDKN1A (physical association, affinity chromatography technology) Amador et al., Mol Cell 2007*
• IRef Hprd Interaction: Complex of CDC20-CDKN1A-CDC27-CDKN1A-CDC27-CDC20-CDKN1A-CDC20-CDC27 (in vivo) Amador et al., Mol Cell 2007*
• IRef Hprd Interaction: Complex of CDKN1A-CDC20-SKP2-SKP2-CDKN1A-CDC20-CDC20-CDKN1A-SKP2 (in vivo) Amador et al., Mol Cell 2007*
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013

Text-mined interactions from Literome

Amador et al., Mol Cell 2007 (Colonic Neoplasms...) : Silencing of Cdc20 induced an accumulation of p21 , increased the fraction of p21 bound to Cdk1, and inhibited Cdk1 activity in p21 ( +/+ ) prometaphase cells, but not in p21 ( -/- ) cells ... Thus, in prometaphase Cdc20 positively regulates Cdk1 by mediating the degradation of p21
Li et al., Gene regulation and systems biology 2008 : Of the five genes tested by quantitative RT-PCR, CDKN1A ( p21 ( waf1 ) ) was up regulated , CDC2/cdk1 , MCM6, ORC1L were down regulated, while ORC3L expression remained unchanged following butyrate treatment