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CD40 — CD8B
Text-mined interactions from Literome
Koenen et al., Blood 2000
:
We hypothesize that in our model, anergy is induced in the CD4 ( + ) T-cell subset, whereby
CD8 ( + ) cytotoxic effector function is
impaired by the lack of both
CD40-CD154 signaling and cytokine mediated help
Samten et al., J Immunol 2003
:
CD40LT enhanced the capacity of M. tuberculosis-responsive
CD8 ( + ) T cells to produce IFN-gamma by increasing the number of IFN-gamma producing CD8 ( + ) T cells and the amount of IFN-gamma produced per cell
Taraban et al., J Immunol 2004
:
Our data indicate that CD70 expression on APCs plays a key role in
CD40 dependent
CD8 T cell responses
Wüthrich et al., J Immunol 2006
(Blastomycosis) :
In the absence of
CD40 or CD40L, CD4 ( + ) cells failed to get primed or produce type 1 cytokine and
impaired the generation of
CD8 ( + ) T1 cells
Shen et al., Exp Oncol 2007
(Carcinoma, Hepatocellular...) :
CD40-B transfected with tumor total RNA can
induce CTLs to express
CD8 and generate IFN-gamma at high levels
Umeshappa et al., J Immunol 2009
(Melanoma, Experimental) :
Their stimulatory effect on CD8 ( + ) CTL responses and antitumor immunity is mediated by IL-2 secretion,
CD40L , and CD80 signaling and is specifically
targeted to
CD8 ( + ) T cells in vivo via acquired pMHC I
Viaud et al., J Immunother 2011
:
Here, we show that interferon-? is a key cytokine conditioning the dendritic cell to
induce the expression of
CD40 , CD80, CD86, and CD54 on Dex, endowing them with direct and potent peptide dependent
CD8 ( + ) T-cell triggering potential in vitro and in vivo
Seah et al., J Leukoc Biol 2013
(Orthomyxoviridae Infections) :
Adoptive transfer of CD40 KO CD8 ( + ) T cells compared with WT cells confirmed that
CD40 on such cells was
critical for the generation of primary anti-influenza
CD8 ( + ) T cell responses
Ballesteros-Tato et al., J Exp Med 2013
(Orthomyxoviridae Infections) :
Nevertheless,
CD40-CD154 interactions are often
required for optimal
CD8 ( + ) T cell responses to pathogens for unknown reasons