Gene interactions and pathways from curated databases and text-mining

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CD40 — CD8B

Text-mined interactions from Literome

Koenen et al., Blood 2000 : We hypothesize that in our model, anergy is induced in the CD4 ( + ) T-cell subset, whereby CD8 ( + ) cytotoxic effector function is impaired by the lack of both CD40-CD154 signaling and cytokine mediated help
Samten et al., J Immunol 2003 : CD40LT enhanced the capacity of M. tuberculosis-responsive CD8 ( + ) T cells to produce IFN-gamma by increasing the number of IFN-gamma producing CD8 ( + ) T cells and the amount of IFN-gamma produced per cell
Taraban et al., J Immunol 2004 : Our data indicate that CD70 expression on APCs plays a key role in CD40 dependent CD8 T cell responses
Wüthrich et al., J Immunol 2006 (Blastomycosis) : In the absence of CD40 or CD40L, CD4 ( + ) cells failed to get primed or produce type 1 cytokine and impaired the generation of CD8 ( + ) T1 cells
Shen et al., Exp Oncol 2007 (Carcinoma, Hepatocellular...) : CD40-B transfected with tumor total RNA can induce CTLs to express CD8 and generate IFN-gamma at high levels
Umeshappa et al., J Immunol 2009 (Melanoma, Experimental) : Their stimulatory effect on CD8 ( + ) CTL responses and antitumor immunity is mediated by IL-2 secretion, CD40L , and CD80 signaling and is specifically targeted to CD8 ( + ) T cells in vivo via acquired pMHC I
Viaud et al., J Immunother 2011 : Here, we show that interferon-? is a key cytokine conditioning the dendritic cell to induce the expression of CD40 , CD80, CD86, and CD54 on Dex, endowing them with direct and potent peptide dependent CD8 ( + ) T-cell triggering potential in vitro and in vivo
Seah et al., J Leukoc Biol 2013 (Orthomyxoviridae Infections) : Adoptive transfer of CD40 KO CD8 ( + ) T cells compared with WT cells confirmed that CD40 on such cells was critical for the generation of primary anti-influenza CD8 ( + ) T cell responses
Ballesteros-Tato et al., J Exp Med 2013 (Orthomyxoviridae Infections) : Nevertheless, CD40-CD154 interactions are often required for optimal CD8 ( + ) T cell responses to pathogens for unknown reasons