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IL6 — REG1A

Text-mined interactions from Literome

Tancredi et al., J Neurochem 2000 (Synaptic Transmission) : We have studied the effects of interleukin-6 (IL-6) on the expression of paired pulse facilitation ( PPF ), posttetanic potentiation (PTP) , and long-term potentiation ( LTP ) in the CA1 region of the hippocampus as well as on the activation of the signal transducer and activator of transcription-3 ( STAT3 ), the mitogen activated protein kinase ERK ( MAPK/ERK ), and the stress activated protein kinase/c-Jun NH ( 2 ) -terminal kinase ( SAPK/JNK ) ... IL-6 induced a marked and dose dependent decrease in the expression of PTP and LTP that could be counteracted by the simultaneous treatment with the tyrosine kinase inhibitor lavendustin A ( LavA ) but did not significantly affect PPF ... The IL-6 induced inhibition of PTP and LTP was accompanied by a simulation of STAT3 tyrosine phosphorylation and an inhibition of MAPK/ERK dual phosphorylation, in the absence of changes in the state of activation of SAPK/JNK
Yao et al., J Biomed Sci 2004 : In the presence of vanadate ( 10 microM ), a PTP inhibitor , IL-6 induced pronounced G0/G1 cell cycle arrest ; this effect was associated with CD14+ monocytic differentiation as well as F-actin filament polymerization
Sekikawa et al., Gut 2005 (Adenoma...) : REG Ialpha promoter activity was enhanced by stimulation with interferon gamma or interleukin 6
Sekikawa et al., Carcinogenesis 2008 : We investigated the involvement of IL-6/STAT3 signaling in REG Ialpha protein expression and examined whether REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells ... The effects of IL-6/STAT3 signaling on REG Ialpha protein expression were examined using a STAT3 small interfering RNA system in gastric cancer cells ... The element responsible for IL-6 induced REG Ialpha promoter activation was determined by a promoter deletion assay