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JAK1 — STAT5B

Pathways - manually collected, often from reviews:

• BioCarta il-7 signal transduction: IL-7/IL-7Ra/IL-2R-gamma/JAK1/JAK3 complex (ITGA2B-Il7r-IL2RG-JAK1-JAK3) → STAT5 (STAT5A/STAT5B) (modification, activates)
• BioCarta il22 soluble receptor signaling pathway: STATs (STAT3/STAT5A/STAT1/STAT5A/STAT5B/STAT5B) → IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) (modification, collaborate)
  
• BioCarta il22 soluble receptor signaling pathway: IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/JAK1/JAK1/IL-22/IL-22R1/IL-22/IL-22/IL-10R2C/TYK2/IL-22/IL-22 complex (IL22-IL22RA1-IL10RA-TYK2-JAK1) → STATS/STATS complex (STAT3_STAT5A_STAT1_STAT5A_STAT5B_STAT5B) (modification, activates)
  
• BioCarta il-2 receptor beta chain in t cell activation: IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2) → Nmi/STAT5 complex (NMI-STAT5A_STAT5B) (modification, activates)
  
• KEGG Jak-STAT signaling pathway: JAK1/JAK2/JAK3/TYK2 → STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6 (protein-protein, phosphorylation)
  
• KEGG Measles: JAK1/JAK3 → STAT3/STAT5A/STAT5B (protein-protein, activation)
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) → STAT5 (STAT5A/STAT5B) (modification, inhibits) Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) → STAT5 (dimer)-active (STAT5B/STAT5A) (modification, inhibits)
  Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) → STAT5 (STAT5A/STAT5B) (modification, inhibits) Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) → STAT5 (dimer)-active (STAT5B/STAT5A) (modification, inhibits)
  Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAT5 (STAT5A/STAT5B) (modification, activates) Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2-mediated signaling events: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3) → STAT5 (dimer)-active (STAT5B/STAT5A) (modification, activates)
  Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
  Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
• NCI Pathway Database IL2 signaling events mediated by STAT5: IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2/SHP2/PI3K complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2-PTPN11-PIK3CA-PIK3R1) → STAT5 (dimer)-active (STAT5B/STAT5A) (transcription, activates)
  Moriggl et al., Immunity 1999, Brennan et al., Immunity 1997
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL4-mediated signaling events: STAT5 (STAT5A/STAT5B) → IL4/IL4R/JAK1/IL2R gamma/JAK3 complex (IL4-IL4R-JAK1-IL2RG-JAK3) (modification, collaborate)
  Mora et al., J Immunol 2001
  Evidence: mutant phenotype, physical interaction, other species
• Reactome Reaction: JAK1 → STAT5B (reaction) Johnston et al., Proc Natl Acad Sci U S A 1995, Lin et al., J Biol Chem 1996, Gaffen et al., J Biol Chem 1996, Behrmann et al., J Biol Chem 1997
• Reactome Reaction: JAK1 → STAT5B (indirect_complex) Johnston et al., Proc Natl Acad Sci U S A 1995, Lin et al., J Biol Chem 1996, Gaffen et al., J Biol Chem 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: JAK1 — STAT5B (physical association, affinity chromatography technology) Fujitani et al., Oncogene 1997*
• IRef Biogrid Interaction: JAK1 — STAT5B (direct interaction, two hybrid) Fujitani et al., Oncogene 1997*

Text-mined interactions from Literome

Sawka-Verhelle et al., Endocrinology 2000 (Carcinoma, Hepatocellular...) : In addition, by using Jak1- and Tyk2-deficient cells we exclude the involvement of both Jak1 and Tyk2 in Stat 5B activation by insulin
Neilson et al., Mol Endocrinol 2007 (Breast Neoplasms) : Finally, suppression of Jak1 by lentiviral delivery of Jak1 short hairpin RNA blocked PRL activation of ERK and signal transducer and activator of transcription ( Stat ) 3 and suppressed PRL activation of Jak2, Stat5a, Stat5b , and Akt, as well as tyrosine phosphorylation of PRLR
Patel et al., J Biol Chem 1996 : In addition to Stat6, Stat5a, and Stat5b , PDGF BB also induced Jak1 tyrosine phosphorylation suggesting a potential pathway for Stat activation