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ADIPOQ — IL6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ADIPOQ → IL6 (decreases, IL6 Translocation)
  Evidence: Recent work from our group shows down-regulation of adiponectin secretion to 75% and mRNA expression to 50% of control levels by IL-6 in 3T3-L1 adipocytes in vitro

Text-mined interactions from Literome

Fasshauer et al., Biochem Biophys Res Commun 2003 (Insulin Resistance) : Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
Wulster-Radcliffe et al., Biochem Biophys Res Commun 2004 : Adiponectin suppressed both TNFalpha and IL6 production in macrophages activated with lipopolysaccharide ( P < 0.01 )
Saijo et al., Biochem Biophys Res Commun 2005 : Adiponectin , an adipocyte derived hormone, reportedly suppresses the production of TNF-alpha and IL-6 by LPS stimulated human or porcine macrophages, and the phagocytosis of microbeads by human macrophages
Weigert et al., FEBS Lett 2005 : Adiponectin exerts anti-inflammatory effects in LPS treated monocytic cells and CORS-26 also reduces IL-6 and TNF-alpha secretion but does not increase IL-10
Abke et al., Cardiovascular diabetology 2006 (Diabetes Mellitus, Type 1) : Adiponectin induced secretion of interleukin-6 (IL-6) , monocyte chemotactic protein-1 ( MCP-1, CCL2 ) and interleukin-8 ( IL-8, CXCL8 ) is impaired in monocytes from patients with type I diabetes
Tang et al., J Immunol 2007 : Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway ... Adiponectin caused concentration- and time dependent increases in IL-6 production ... Adiponectin mediated IL-6 production was attenuated by AdipoR1 and 5'-AMP activated protein kinase ( AMPK ) alpha1 small interference RNA
Lü et al., Diabetes Res Clin Pract 2009 (Albuminuria...) : Adiponectin level and Gutt 's index decreased, but IL-6 level and ACR increased gradually among NGT, PD and NDDM groups ( P < 0.01 )
Choi et al., Arthritis Res Ther 2009 (Arthritis, Rheumatoid...) : Adiponectin at the concentration of 10 microg/mL stimulated the production of IL-6 , IL-8, and PGE2 in RA fibroblast-like synoviocytes ( FLSs ), although the level of these was much lower than with 1 ng/mL IL-1beta
Fan et al., J Cell Physiol 2011 : Adiponectin induces interleukin-6 production and its underlying mechanism in adult rat cardiac fibroblasts
Zhou et al., Cardiovascular diabetology 2011 (Coronary Artery Disease) : Adiponectin suppressed secretion of IL-6 and TNF-a in stimulated monocytes and TLR4 was expressed on cell surfaces