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MAPK1 — PTPN1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK1
→
PTPN1
(increases, MAPK1 Activity)
Liang et al., J Biol Chem 2005*
Evidence: We show that down-regulation of PTP1B activity with small molecule inhibitors suppresses cell spreading and migration to fibronectin, increases Tyr(527) phosphorylation in Src, and decreases phosphorylation of FAK, p130(Cas), and ERK1/2.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Egawa et al., J Biol Chem 2001
(Carcinoma, Hepatocellular...) :
In both cells,
PTP1B overexpression blocked insulin stimulated tyrosine phosphorylation of the insulin receptor and IRS-1 by more than 70 % and
resulted in a significant inhibition of the association between IRS-1 and the p85 subunit of phosphatidylinositol 3-kinase and Akt phosphorylation as well as
mitogen activated protein kinase phosphorylation
Shimizu et al., Endocrinology 2002
:
Mechanism for differential
effect of
protein-tyrosine phosphatase 1B on Akt versus
mitogen activated protein kinase in 3T3-L1 adipocytes ... Overexpression of a wild-type
PTP1B in L1 adipocytes as well as in L6 myocytes,
led to a profound decrease in insulin stimulated phosphorylation of
MAPK
Nakamura et al., Circ Res 2008
(Disease Models, Animal...) :
VEGF induced p38
mitogen activated protein kinase phosphorylation and EC migration are not
affected by
PTP1B overexpression or knockdown
Venkatesan et al., FASEB J 2008
:
Interestingly, resveratrol
increased the activity of protein tyrosine phosphatase
PTP1B , which dephosphorylates PDGF stimulated phosphorylation at tyrosine-751 and tyrosine-716 on PDGFR with concomitant reduction in Akt and
Erk1/2 kinase activity
Wang et al., Med Oncol 2012
(Disease Progression...) :
Overexpression of
PTP1B promoted the proliferation and in vivo tumorigenesis of MKN45 cells and also
increased the phosphorylation levels of Akt,
Erk1/2 , and FAK and the activity of Src
Liu et al., Mol Cell Biol 1998
(Cell Transformation, Neoplastic) :
Expression of
WT-PTP1B reduces formation of p130Cas-Crk complexes and
inhibits mitogen activated protein kinase activation by Src and Crk