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CTCF — MYC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYC → CTCF (directlyDecreases, MYC Activity)
  Evidence: CD40 signaling also acts to suppress the expression of the gene encoding CTCF, which is a transcription factor that represses c-myc expression, thus allowing sustained c-myc expression and cell cycle progression
• BioCarta ctcf: first multivalent nuclear factor: c-MYC (MYC) → CTCF (transcription, activates)
• FastForward regulation: CTCF → MYC (transcriptional regulation, unknown) Filippova et al., Mol Cell Biol 1996*
  Evidence: DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Innatedb Interaction: MYC — CTCF (unknown, -) Chang et al., PloS one 2010*

Text-mined interactions from Literome

Chau et al., J Virol 2006 : We also show that c-MYC , as well as EBNA2, can stimulate CTCF mRNA levels, suggesting that CTCF levels may contribute to B-cell differentiation as well as EBV latency type determination
Gombert et al., PloS one 2009 : Targeted deletion of multiple CTCF binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression