Gene interactions and pathways from curated databases and text-mining

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CD28 — IL8

Text-mined interactions from Literome

Okkenhaug et al., Nat Immunol 2001 : Nonetheless, this mutated form of CD28 still prevents the induction of anergy and promotes T cell proliferation, interleukin 2 secretion and B cell help
Shapiro et al., Blood 2001 (Disease Progression...) : Furthermore, stimulation of endogenous CD28 expressed by 3 myeloma cell lines increased IL-8 production
Marin et al., Exp Hematol 2007 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Moreover, the presence of 4-1BB or CD28 in the receptor increased the production of interleukin (IL)-2, tumor necrosis factor (TNF)-alpha, TNF-beta, IL-5, IL-6, and IL-8 elicited by coculture with ALL cells
Abreu et al., Arthritis Res Ther 2010 (Arthritis, Experimental...) : Ex vivo, Rac1 inhibitory peptide suppressed T-cell receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help
Dagur et al., J Autoimmun 2011 (Autoimmune Diseases...) : Upon TCR stimulation with CD3/CD28 , CD4 ( + ) CD146 ( + ) T cells secrete significantly more IL-17A, IL-6, and IL-8 than do CD4 ( + ) CD146 ( - ) T cells