Bitomsky et al., Oncogene 2008
:
We have found that diminished Pdcd4 expression leads to increased expression of p21 ( Waf1/Cip1 ) and several other p53 regulated genes
Cox et al., J Pathol 1997
(Cell Transformation, Neoplastic) :
Current research highlights the action of a p53 activated gene, p21Cip1/WAF1/Sdi1, which encodes a cyclin-kinase inhibitor important in mediating p53 dependent cell-cycle arrest, while programmed cell death in response to DNA damage requires transcriptionally active p53 but not activation of p21Cip1/WAF1/Sdi1