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LPO — SLCO6A1

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Vieira et al., Chemosphere 2009 : Significant alterations by both metals on biomarkers were found including : inhibition of AChE and EROD activities, induction of LDH, GST and anti-oxidant enzymes, and increased LPO levels, with LOEC values ranging from 25 to 200 microg L ( -1 ), for copper and from 3 to 25 microg L ( -1 ) for mercury ( dissolved throughout metal concentrations )
Adaramoye et al., Afr J Med Med Sci 2010 (Disease Models, Animal...) : GNH2 treatment markedly increased the levels of serum ALT and AST, which were significantly ( p < 0.05 ) attenuated in animals pretreated with CLME and VC. Also, CLME significantly ( p < 0.05 ) increased the levels of hepatic GST and SOD, with a concomitant marked reduction in the levels of hepatic and serum LPO in the GNH2 challenged mice. Furthermore, hepatic GSH which was decreased after GNH2 intoxication, was significantly ( p < 0.05 ) enhanced by cotreatment with CLME and VC. However, there were no significant differences ( p > 0.05 ) in the levels ofALP and CAT of these animals