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TFRC — WNT2
Text-mined interactions from Literome
Ponka et al., Int J Biochem Cell Biol 1999
(Anoxia) :
However, some cells and tissues with specific requirements for iron probably evolved mechanisms that can override the
IRE/IRP dependent control of
transferrin receptor expression
Tacchini et al., Hepatology 2002
(Ischemia) :
In conclusion, HIF-1 mediated activation of TfR gene transcription and
IRP mediated increase of
TfR mRNA stability ensure a steady induction of TfR, and hence higher iron uptake in reperfused rat liver
Bonnah et al., Cell Microbiol 2004
(Meningococcal Infections) :
This finding suggests that low
IRP activity may be
responsible in part for the decrease in
TfR-1 mRNA levels
Bradley et al., Am J Physiol Regul Integr Comp Physiol 2004
:
Placental
TfR-1 and FPN-1 protein expression was
independent of fetal or placental iron status and
IRP activities
Kohgo et al., Alcohol Clin Exp Res 2005
(Liver Diseases, Alcoholic) :
The increase of
TfR1 expression is partially
due to the increased activity of
iron regulatory protein (IRP) by oxidative stress of ethanol metabolism
Kerenyi et al., Blood 2008
(Anemia, Iron-Deficiency...) :
This reduction could be attributed to reduced transcription of TfR-1 mRNA and
iron regulatory protein 2 (IRP-2) , the major translational
regulator of
TfR-1 mRNA stability in erythroid cells
DeRusso et al., J Biol Chem 1995
:
Thus, a single mutant
IRP can
prevent the usual homeostatic changes in ferritin and
TfR biosynthesis
Coccia et al., Eur J Biochem 1997
(Leukemia, Experimental) :
The regulation of
transferrin receptor and ferritin in response to iron perturbations has been studied extensively and is
mediated by the binding of
iron-regulatory proteins (IRP) to the iron-responsive elements ( IRE ) present in the 3 ' and 5 ' untranslated regions of the transferrin-receptor and ferritin mRNA, respectively
Georgieff et al., Placenta 1999
(Fetal Diseases...) :
The study provides direct in vivo evidence for
IRP regulation of
TfR expression in the human placenta