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NET1 — RHOA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RHOA → NET1 (increases, NET1 Activity, RHOA Activity) Shen et al., J Biol Chem 2001*
  Evidence: NET1 is a guanine nucleotide exchange factor for RhoA NET1 is important for the increase of Rho activity
• NCI Pathway Database Regulation of RhoA activity: NET1 (NET1) → RHOA/GTP complex (RHOA) (modification, activates) Alberts et al., EMBO J 1998*
  Evidence: assay
• NCI Pathway Database Regulation of RhoA activity: NET1 (NET1) → RHOA/GDP complex (RHOA) (modification, activates) Alberts et al., EMBO J 1998*
  Evidence: assay
• Reactome Reaction: RHOA → NET1 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RHOA — NET1 (direct interaction, two hybrid) Alberts et al., J Biol Chem 1998*

Text-mined interactions from Literome

Guerra et al., PloS one 2008 : Expression of a dominant negative Net1 or Net1 knock down by iRNA prevented RhoA activation, inhibited the formation of stress fibers, and enhanced cell death, indicating that Net1 activation is required for this RhoA mediated responses to genotoxic stress
Nakaya et al., Nat Cell Biol 2008 : We propose that loss of Net1 before EMT reduces basal RhoA activity and destabilizes basal microtubules, causing disruption of epithelial cell-BM interaction and subsequently, breakdown of the BM
Murray et al., Br J Cancer 2008 (Adenocarcinoma...) : NET1 mediated RhoA activation facilitates lysophosphatidic acid induced cell migration and invasion in gastric cancer
Lee et al., J Biol Chem 2010 : Using small interfering RNAs, we found that NET1 , the guanine nucleotide exchange factor of RhoA, is critical for TGF-beta1 induced cytoskeletal reorganization, N-cadherin expression, and RhoA activation
Dubash et al., PloS one 2011 : The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals ... We further demonstrate that a fraction of RhoA resides in the nucleus, and can also be found in a GTP bound active form and that Net1 plays a role in the activation of nuclear RhoA
Carr et al., Cell Adh Migr 2013 : The ability of Net1A to stimulate RhoA activation is negatively regulated by nuclear sequestration