UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

MAP2K2 — PAK1

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: MAP2K2 → PAK1 (increases, PAK1 Activity, MAP2K2 Activity)
Evidence: Modified assertion
KEGG Natural killer cell mediated cytotoxicity: PAK1 → MAP2K1/MAP2K2 (protein-protein, activation)
WikiPathways Focal Adhesion: PAK1/PAK3/PAK2/PAK4/PAK7/PAK6 → SEPP1/MAP2K5/MAP2K6/MAP2K2/MAP2K3/MAP2K1 (activation)

Text-mined interactions from Literome

Jung et al., Eur J Biochem 2004 (Melanoma) : However, Rho associated kinase, MAP kinase kinase 1/2 or phospholipase C might not be involved in LPA induced PAK1 activation or cell motility stimulation
Lim et al., Endocrinology 2009 : Knockdown or inhibition of Cdc42 and PAK1 activities also prevented activation of MAPK/ERK (MEK)-1/2-ERK1/2 by insulin, which was previously identified as a critical pathway for insulin regulated GLP-1 release
Lin et al., Front Biosci (Elite Ed) 2010 : In addition, inhibition of PAK1 resulted in abnormal localization of mitogen activated protein kinase kinase ( MEK )