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KRAS — PTGS2
Text-mined interactions from Literome
Taylor et al., Cancer Res 2000
(Colonic Neoplasms) :
Sulindac sulfone inhibits
K-ras dependent
cyclooxygenase-2 expression in human colon cancer cells
Sheng et al., Cancer Res 2001
(MAP Kinase Signaling System) :
Here we investigate the role of Akt/PKB in
K-Ras mediated induction of
COX-2 ... Inhibition of MAPK/ERK kinase activity by PD 98059 completely blocked the K-Ras mediated induction of COX-2, whereas inhibition of PI3K/Akt/PKB activity with LY 294002 or by expressing a dominant negative Akt ( Akt-K179M ) partially blocked the
induction of
COX-2 by
K-Ras ... Thus, Akt/PKB activity is involved in
K-Ras induced expression of
COX-2 and stabilization of COX-2 mRNA largely depends on the activation of Akt/PKB
Araki et al., Cancer Res 2003
:
Although beta-catenin alone did not increase COX-2 protein to detectable levels in HuH7 cells, coexpression of both mutant beta-catenin and mutant
K-ras increased
COX-2 protein expression, which is consistent with the previous reports that K-ras can stabilize COX-2 mRNA
Smakman et al., Clin Cancer Res 2005
(Colorectal Neoplasms...) :
This study was designed to clarify that relationship and to assess the contribution of
KRAS dependent
COX-2 to the seeding of CRC cells in the liver and to their outgrowth as liver metastases in an experimental mouse model ... The contribution of
KRAS dependent
COX-2 to early metastatic tumor cell seeding ( by intravital microscopy ) and outgrowth of metastases in the liver ( by bioluminescence imaging ) was studied by using parecoxib, a novel and highly selective liver activated COX-2 inhibitor
Li et al., Acta Oncol 2006
(Stomach Neoplasms) :
Recent studies have suggested that
K-ras play an important role in the induction of
COX-2 expression in tumor cells
Wu et al., Arch Toxicol 2010
(Colorectal Neoplasms) :
K-ras induces HT29 cells proliferation through the expressions of
COX-2 , EP1/EP4, pAkt, GSK3beta and increases Tcf transcriptional factor activation