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RAB7B — TLR4

Text-mined interactions from Literome

Wang et al., Blood 2007 : Lysosome associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4 ... Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of tumor necrosis factor (TNF)-alpha, IL-6, nitric oxide, and IFN-beta, and potentiate LPS induced activation of mitogen activated protein kinase, nuclear factor kappaB, and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4
Yao et al., J Immunol 2009 (Inflammation) : Our previous study shows that Rab7b can negatively regulate TLR4 signaling by promoting lysosomal degradation of TLR4