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Ueda et al., J Biol Chem 2001
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Galpha11 induces caspase mediated proteolytic activation of Rho associated kinase, ROCK-I , in HeLa cells
Söderström et al., J Cell Sci 2005
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CD95 activated RhoA exclusively in the type II cell, whereas ROCK activation was caspase dependent in the type I cell
Sapet et al., Blood 2006
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Thrombin induced endothelial microparticle generation : identification of a novel pathway involving ROCK-II activation by caspase-2 ... The involvement of caspase-2 in ROCK-II activation independently of cell death points out a novel signaling pathway that emphasizes the proteolytic activity of caspase in EMP generation in response to cell activation
Koyanagi et al., J Neurosci Res 2008
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Membrane blebbing, which is an early morphological sign of apoptosis ; cleavage of caspase-3 ; and release of cytochrome c from the mitochondria are also reduced by ROCK inhibition