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GRAP2 — IL1B

Text-mined interactions from Literome

Tominaga et al., Aliment Pharmacol Ther 2000 (Inflammation) : To investigate whether IL-1beta activates MAP kinases [ extracellular signal regulated kinases ( ERKs ), c-Jun NH2-terminal kinases (JNKs) and p38 MAP kinase (p38 MAPK) ] and nuclear factor (NF)-kappaB
Tanaka et al., J Mol Cell Cardiol 2000 (MAP Kinase Signaling System) : While IL-1 beta phosphorylated c-Jun N-terminus protein kinase (JNK) rapidly and transiently, the effect of IL-1 beta on p38 mitogen activated protein kinase ( MAPK ) was gradual and persistent
Birrell et al., Eur Respir J 2000 (Pneumonia...) : SB 203580 is a pyridinyl imidazole compound which inhibits the release of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) , in vitro and in vivo by inhibiting p38 mitogen activated protein kinase ( MAPK )
Ng et al., J Biol Chem 2001 (Hypertrophy...) : The specific inhibition of either ERK or p38 ( MAPK ) attenuated the IL-1 beta- or LIF stimulated ANF expression by up to 70 %
Lu et al., Chin Med J (Engl) 2000 (Arthritis, Rheumatoid) : IL-1 beta transiently increased protein tyrosine phosphorylation, and activated the MAPKs cascades ( mainly ERK2, JNK2 and P38 ) in RA FLS
Guo et al., J Biol Chem 2003 (Inflammation) : This strategy established the requirement for p38 activity for the lipopolysaccharide stimulated production of IL-10, IL-1beta , and IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and TNFalpha stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9
Degousee et al., Circ Res 2003 (MAP Kinase Signaling System) : Infecting cardiomyocytes with adenoviruses that encode mutant, phosphorylation-resistant MKK6 or p38beta2 MAPK inhibited interleukin-1beta induced p38 MAPK activation , COX-2 gene expression, and PGE2 release
Yoshino et al., J Clin Endocrinol Metab 2003 : P38 MAPK phosphorylation was increased by IL-1 beta in nondecidualized ESC, whereas the IL-1 beta induced increase was suppressed in the decidualized cells
Utani et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Studies with specific inhibitors of MAPKs showed that p38 MAPK activation was necessary for both IL-1 beta and MMP-1 induction, but Erk activation was required only for MMP-1 induction
Fumimori et al., J Rheumatol 2004 (Arthritis, Rheumatoid) : EM suppressed the IL-1beta induced COX-2 protein expression in a dose dependent manner and inhibited IL-1beta induced p38 MAPK phosphorylation, which was correlated with COX-2 expression in synovial cells
Masamune et al., J Pharmacol Exp Ther 2004 : SP600125 inhibited interleukin-1beta induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular regulated kinase, p38 mitogen activated protein kinase, and nuclear factor-kappaB
Nolan et al., J Neuroimmunol 2004 : Lipopolysaccharide (LPS) has a negative impact on long-term potentiation ( LTP ) in the rat hippocampus, which has been correlated with increased concentration of interleukin-1 beta (IL-1 beta) and activation of p38 and c-Jun N-terminal kinase (JNK)
Hwang et al., Oncogene 2004 (Stomach Neoplasms) : IL-1beta induced the activation of extracellular signal regulated kinases-1/2 and P38 mitogen activated protein kinase ( MAPK ), but not the activation of c-jun amino-terminal kinse and Akt
Lajaunias et al., Eur J Immunol 2005 (Inflammation) : Simultaneous addition of both inhibitors resulted in low levels of IL-1 beta, suggesting that CD33 exerts an inhibitory role mediated by PI3K, while p38 MAPK signaling is required for IL-1 beta production
Kher et al., J Thorac Cardiovasc Surg 2005 (Reperfusion Injury) : The kidney was analyzed for expression of tumor necrosis factor alpha, interleukin 1beta , and interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and activation of p38 mitogen activated protein kinase, caspase 3, and caspase 8 ( Western blot )
Larsen et al., Diabetologia 2006 (Insulinoma...) : In INS-1E and beta-TC3 cells, expression of Gadd45b inhibited IL-1beta induced activation of JNK and ERK, but augmented IL-1beta mediated p38 activity
Liu et al., Endocrinology 2006 : IL-1beta caused an increase in the phosphorylation of ERK, but not p38MAPK or c-Jun N-terminal kinase
Arkusz et al., Toxicol In Vitro 2007 : Interleukin-1beta expression in murine J774A.1 macrophages exposed to platinum compounds : the role of p38 and ERK 1/2 mitogen activated protein kinases
Sodhi et al., Glycoconj J 2007 : Pharmacological inhibitor of tyrosine kinase, PI3 kinase, protein kinase C, p42/44, p38 , JNK and intracellular calcium immobilizing agent down regulated the WGA induced expression of cytokines TNF-alpha, IL-1beta , IL-12 and IFN-gamma
Illek et al., Am J Physiol Lung Cell Mol Physiol 2008 : It is concluded that : 1 ) flagellin and IL-1beta activated p38 , NF-kappaB, IL-8, and CFTR dependent anion secretion without altering tight junction permeability ; 2 ) p38 played a role in regulating I ( Cl ) and IL-8 but not NF-kappaB ; and 3 ) p38 was more important in flagellin- than IL-1beta stimulated responses
du Souich et al., J Cell Mol Med 2009 : In chondrocytes, CS diminishes interleukin-1 beta(IL-1beta) induced increases in p38 mitogen activated protein kinase ( p38MAPK ) and signal regulated kinase 1/2 ( Erk1/2 ) phosphorylation, and decreases nuclear factor-kappaB (NF-kappaB) nuclear translocation and as a consequence, reduces the formation of pro-inflammatory cytokines, IL-1beta and TNF-alpha, and pro-inflammatory enzymes, such as phospholipase A2 (PLA2), cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2)
Shimpo et al., J Orthop Sci 2009 (Osteoarthritis) : IL-1beta strongly increased the translocation of NF-kappaB to the nucleus and the phosphorylation of extracellular-signal regulated kinase, p38 , and c-Jun amino-terminal kinase ; but the up-regulation was not inhibited by DEX or COX inhibitors
Liu et al., Proc Natl Acad Sci U S A 2009 : Neither JNK1 activation by IL-1beta or UV nor TNF-alpha induced activation of p38 , ERK, or IkappaB kinase complex is affected by the loss of Miz1
Guan et al., Am J Physiol 1998 : Our data also indicate that both insulin and IGF-I enhance IL-1 beta induced p38 mitogen activated protein kinase ( MAPK ) phosphorylation and SAPK activation
Larsen et al., J Biol Chem 1998 : By Western blotting with phosphospecific antibodies and by immunocomplex kinase assay, IL-1beta was shown to activate extracellular signal regulated kinase ( ERK ) 1/2 and p38 mitogen activated protein kinase ( p38 ) in islets and rat insulinoma cells