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PGC — PRKAA1
Text-mined interactions from Literome
Lee et al., Biochem Biophys Res Commun 2006
:
Here we show that
AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside ( AICAR )
increases mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of PPARalpha and
PGC-1 by siRNAs prevents AICAR stimulated increase in fatty acid oxidation
Lira et al., J Physiol 2010
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Nitric oxide and
AMPK cooperatively
regulate PGC-1 in skeletal muscle cells
Łabuzek et al., Pharmacol Rep 2010
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Furthermore, the effects of metformin on the release of IL-1ß, IL-6, IL-10, TGF-ß, NO, and ROS as well as on the expression of arginase I, iNOS, NF-?B p65 and
PGC-1a were not
AMPK dependent , because pretreatment of LPS activated microglia with compound C, a pharmacological inhibitor of AMPK, did not reverse the effect of metformin
Beharry et al., Proc Natl Acad Sci U S A 2011
:
Overexpression of
PGC-1a in TKO MEFs elevated ATP levels and
inhibited the activation of
AMPK
Birkenfeld et al., Cell Metab 2011
(Insulin Resistance...) :
Deletion of mIndy in mice ( mINDY ( -/- ) mice ) reduces hepatocellular ATP/ADP ratio, activates hepatic
AMPK ,
induces PGC-1a , inhibits ACC-2, and reduces SREBP-1c levels
Norrbom et al., Am J Physiol Endocrinol Metab 2011
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AMPK phosphorylation increased to a greater extent in the R-leg, and AICAR stimulation of cultured human myotubes
induced the expression of PGC-1a-a and
PGC-1a-b
Smith et al., J Physiol 2013
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These data suggest that exercise causes translocation of
PGC-1a preferentially to SS mitochondria in an
AMPK dependent manner
Wang et al., Int J Biochem Cell Biol 2013
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Erythropoietin also increases
AMPK , which
induces PGC-1a and stimulates slow oxidative fiber formation