◀ Back to PIK3R1
PIK3R1 — SYK
Pathways - manually collected, often from reviews:
-
KEGG Natural killer cell mediated cytotoxicity:
SYK
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Fc epsilon RI signaling pathway:
SYK
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
KEGG Fc gamma R-mediated phagocytosis:
SYK
→
PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5
(protein-protein, activation)
-
NCI Pathway Database Fc-epsilon receptor I signaling in mast cells:
Antigen/IgE/Fc epsilon R1/LYN/SYK complex (IGHE-SYK-LYN-MS4A2-FCER1G-FCER1A)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Manetz et al., Mol Cell Biol 2001, Barker et al., Mol Biol Cell 1995
Evidence: assay, other species
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1)
(modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/LYN/SYK complex (LYN-SYK-CD79B-CD79A)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Okada et al., Immunity 2000, Weng et al., J Biol Chem 1994
Evidence: assay, physical interaction
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SYK complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SYK)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Jiang et al., Blood 2003
Evidence: mutant phenotype
-
NCI Pathway Database FAS (CD95) signaling pathway:
FASLG/FAS (trimer)/Src/Syk complex (FAS-FASLG-SRC-SYK)
→
PI3K Class IA family (PIK3CA/PIK3R1/PIK3CB/PIK3R1)
(modification, activates)
Beier et al., J Neurosci 2005, Letellier et al., Immunity 2010
-
Reactome Reaction:
SYK
→
PIK3R1
(indirect_complex)
Jiang et al., J Immunol 2002, Leverrier et al., J Biol Chem 2003, Moon et al., J Biol Chem 2005
-
Reactome Reaction:
SYK
→
PIK3R1
(reaction)
Jiang et al., J Immunol 2002, Leverrier et al., J Biol Chem 2003, Moon et al., J Biol Chem 2005
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SYK
—
PIK3R1
(physical association, affinity chromatography technology)
Moon et al., J Biol Chem 2005
-
IRef Biogrid Interaction:
SYK
—
PIK3R1
(direct interaction, pull down)
Moon et al., J Biol Chem 2005
-
IRef Biogrid Interaction:
SYK
—
PIK3R1
(direct interaction, two hybrid)
Moon et al., J Biol Chem 2005
-
IRef Biogrid Interaction:
SYK
—
PIK3R1
(physical association, affinity chromatography technology)
Huang et al., J Leukoc Biol 2006
-
IRef Hprd Interaction:
Complex of CBL-SYK-PIK3R1-PIK3R1-SYK-CBL-SYK-CBL-PIK3R1
(in vivo)
Grossmann et al., FEBS Lett 2004
-
IRef Hprd Interaction:
SYK
—
PIK3R1
(two hybrid)
Moon et al., J Biol Chem 2005
-
IRef Innatedb Interaction:
SYK
—
PIK3R1
(unknown, -)
Huang et al., J Leukoc Biol 2006
-
IRef Intact Interaction:
SYK
—
PIK3R1
(physical association, pull down)
Moon et al., J Biol Chem 2005
-
IRef Intact Interaction:
SYK
—
PIK3R1
(physical association, two hybrid)
Moon et al., J Biol Chem 2005
-
IRef Intact Interaction:
SYK
—
PIK3R1
(physical association, anti bait coimmunoprecipitation)
Moon et al., J Biol Chem 2005
-
IRef Intact Interaction:
Complex of SYK-LYN-PIK3R1-CD22
(association, coimmunoprecipitation)
Tuscano et al., Eur J Immunol 1996*
Text-mined interactions from Literome
Qin et al., Biochemistry 2003
:
Under our conditions, hydrogen peroxide induced
PI3K and Akt activation was
independent of Lyn,
Syk , Cbl, BCAP, or Ras when each was eliminated individually either by mutation or by a specific inhibitor
Peruzzi et al., J Immunol 2007
(Calcium Signaling) :
Altogether, our findings support a new
role for
CIN85 in regulating
Syk protein levels in RBL-2H3 cells through the activation of the ubiquitin-proteasome pathway and provide a mechanism for this regulation involving c-Cbl ligase activity
Lau et al., J Immunol 2008
:
We postulated that
Syk regulates
PI3K activation and HRV endocytosis in the airway epithelium ... HRV induced
PI3K activation was
dependent on
Syk ; Syk knockdown by small interfering RNA significantly decreased phosphorylation of the PI3K substrate Akt
Chiou et al., Eur J Pharmacol 2011
:
Psoralidin inhibits LPS induced iNOS expression via repressing
Syk mediated activation of
PI3K-IKK-I?B signaling pathways
Hatton et al., PloS one 2012
(Lymphoma, B-Cell) :
Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes
Syk to
activate PI3K/Akt signaling and induce IL-10 production
Hatton et al., Am J Transplant 2013
(Epstein-Barr Virus Infections...) :
Taken together, our data indicate that
Syk activates
PI3K/Akt signaling which is required for survival of EBV+ B cell lymphomas
Zheng et al., Exp Cell Res 2013
:
Our data indicate that TMP might repress iNOS expression, at least in part, through its inhibitory effect of
Syk mediated
PI3K phosphorylation in TNF-a stimulated HUVECs