Byfield et al., J Biol Chem 2005
:
The Class IA phosphatidylinositol (PI) 3-kinase plays a well recognized role in the regulation of S6K1 ... We now present evidence that the Class III PI 3-kinase , hVps34, also regulates S6K1 , and is a critical component of the nutrient sensing apparatus
Adochio et al., Endocrinology 2009
(Insulin Resistance) :
Reduction in expression of either p85alpha or S6K1 achieved with small interfering RNA in the presence of myristoylated Akt rescued 3T3-L1 adipocytes from the insulin resistance induced by serine phosphorylation of IRS-1 and completely restored insulin stimulated activation of PI 3-kinase and glucose uptake
Hamilton et al., BMC cell biology 2010
:
Prolonged activation of S6K1 does not suppress IRS or PI-3 kinase signaling during muscle cell differentiation