Laws et al., Eur J Immunol 2004
:
p53 regulates Presenilin1 (PS1) expression, and PS1 cleaves Notch, releasing its intracellular domain ( NIC ), leading to the expression of downstream targets, e.g. the HES1 gene
Bialopiotrowicz et al., J Alzheimers Dis 2012
(Alzheimer Disease) :
Altogether, we found that both CC regulation and Aß production differentiate PS1 mutations, and that CC PS1 activity is mediated by p53/p21 signaling but not by ?-secretase activity