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EGF — VEGFA

Text-mined interactions from Literome

Tsai et al., J Formos Med Assoc 1999 (Meningeal Neoplasms...) : By means of an enzyme linked immunosorbent assay of CH-157MN meningioma cell supernatants, we demonstrated that EGF and bFGF similarly induce VEGF secretion by CH-157MN meningioma cells
Valter et al., Int J Dev Neurosci 1999 (Glioma...) : EGF also stimulated the secretion of VEGF into the cell supernatant ... In general, the effects of IL-1 and EGF on VEGF were additive, suggesting independent mechanisms
Wu et al., J Biol Chem 2000 : However, blockade of PKC diminished thymidine incorporation into DNA induced by VEGF but not FGF or EGF
Fujiyama et al., Circ Res 2001 : Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF) mediated EGF receptor transactivation ... Ang II also upregulated vascular endothelial growth factor ( VEGF ) expression in an HB-EGF/EGFR dependent manner
Redondo et al., Arch Dermatol Res 2000 : HKC showed baseline expression and a progressive gradual time dependent increase in VEGF secretion ( 510+/-75 pg/ml at 24 h ), and EGF ( 2.5-100 ng/ml ) enhanced the secretion of VEGF in a dose dependent fashion
Ravindranath et al., J Androl 2001 (Carcinoma...) : Because progression of prostate cancer is accompanied by altered expression of epidermal growth factor (EGF) and its receptor ( EGFR ) in malignant cells, we investigated the effect of EGF on VEGF gene expression by Northern blot analysis in 2 human prostate cancer cell lines that express EGFR ... The EGF induction of VEGF gene expression suggests a mechanism by which angiogenesis could be accelerated in BPH and prostate carcinoma
Bancroft et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : In our study, we examined the effect of EGF and antagonists of EGFR, PI3K and MEK on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in HNSCC cell lines UM-SCC-9 and 11B in which EGFR is overexpressed and activated ... Recombinant EGF induced EGFR phosphorylation, activation of NF-kappaB and AP-1 reporter genes and IL-8 and VEGF expression, indicating that EGFR can mediate coactivation of both transcription factors and cytokine genes in HNSCC
Kawano et al., Clin Exp Med 2002 : The effect of epidermal growth factor on vascular endothelial growth factor secretion by endometrial stromal cells ... We studied physiological induction by epidermal growth factor (EGF) of vascular endothelial growth factor ( VEGF ) in these cells ... In human endometrial stromal cells, the effect of EGF , genistein, tryphostin AG1478 ( a tyrosine kinase inhibitor ), and wortmannin ( a phosphatidylinositol 3-kinase inhibitor ) on production of VEGF was examined ... EGF induced production of VEGF by stromal cells in a time dependent manner ; the effect became significant after 12 h and increased further between 24 and 48 h ( P < 0.05 )
Akagi et al., Br J Cancer 2003 (Stomach Neoplasms) : Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells ... Moreover, in EGF-R positive NCI-N87 and ST-2 cells, EGF induced both NRP-1 and VEGF mRNA expression ... C225, a monoclonal antibody to EGF-R, blocked EGF induced NRP-1 and VEGF expression in NCI-N87 cells in a dose dependent manner ... Blockade of the Erk, phosphatidylinositol-3 kinase/Akt, or P38 pathways in this cell line prevented EGF induction of NRP-1 and VEGF
Huang et al., Zhonghua Zhong Liu Za Zhi 2002 (Carcinoma, Hepatocellular...) : Recombinant human EGF could induce the expression of VEGF in HepG ( 2 ) cells in a dose and time dependent manner ... The expression of EGF in HCC underlies the overexpression of VEGF in HCC
Tsai et al., Biochem Biophys Res Commun 2003 (Glioma) : PTK inhibitors blocked glioma proliferation and epidermal growth factor (EGF) induced VEGF secretion, while H-7, a PKC inhibitor, inhibited both EGF induced and baseline VEGF secretion ... All inhibitors ( genistein, AG18, AG213, H-7, prolonged PMA treatment ) which inhibited EGF induced VEGF secretion in glioma cells also inhibited cell proliferation at similar concentrations
Huang et al., World J Gastroenterol 2004 (Carcinoma, Hepatocellular...) : Also, 25 ng/mL recombinant human EGF stimulated the expression of VEGF in HepG ( 2 ) cells and the expression increased with the increase of EGF concentration ... The overexpression of VEGF in HCC could be promoted by hypoxia and EGF expression in HCC
Horiguchi et al., Endocrine 2004 : Regulation of VEGF-A , VEGFR-I, thrombospondin-1, -2, and -3 expression in a human pituitary cell line ( HP75 ) by TGFbeta1, bFGF, and EGF ... Basic FGF and EGF did not modulate changes in VEGF-A mRNA levels after 4 and 24 h of treatment, but EGF increased VEGF-A significantly ( p < 0.05 ) after 96 h of treatment
Lee et al., Anticancer Res 2004 (Breast Neoplasms) : Effect of estrogen, tamoxifen and epidermal growth factor on the transcriptional regulation of vascular endothelial growth factor in breast cancer cells
Sini et al., Clin Cancer Res 2005 (Neoplasms, Experimental) : In an in vitro angiogenesis assay, epidermal growth factor (EGF) stimulated the release of VEGF by smooth muscle cells resulting in increased angiogenesis, a response blocked by administration of PTK787/ZK222584
Kawano et al., Growth Factors 2005 (MAP Kinase Signaling System) : The effect of epidermal growth factor on production of vascular endothelial growth factor by amnion derived ( WISH ) cells ... WISH cells were cultured, and the effect of epidermal growth factor (EGF) , mitogen activated protein ( MAP ) kinase kinase or extracellular signal regulated kinase ( ERK ) kinase ( MEK ) inhibitors ( U0126 ) or phosphatidylinositol (PI) 3-kinase on the production of VEGF was examined ... EGF increased the production of VEGF by WISH cells in a dose dependent manner ... It is suggested that VEGF may contribute to the neovascularization and proliferation of the placenta and gestational tissue, and EGF may play an important role in regulation of VEGF production in the placenta
Summy et al., Pancreas 2005 (MAP Kinase Signaling System...) : c-Src regulates constitutive and EGF mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK ... Inhibition of Src activity or expression decreases both constitutive and EGF induced VEGF production ... Both the PI3K/Akt and p38 MAPK pathways are activated in a Src family kinase dependent fashion on EGF-R activation and are important for EGF mediated VEGF production in pancreatic cancer cells ... Src activity contributes to constitutive and EGF induced VEGF expression and angiogenic potential in pancreatic cancer cells
Cole et al., Anticancer Res 2006 (Mesothelioma...) : A substantial reduction of cell motility, Matrigel invasion as well as inhibition of basal or EGF induced VEGF production were observed in drug treated cells
Lombardero et al., Pituitary 2006 : At 2 hours, EGF and TGFbeta caused no significant changes in VEGF and Flk-1 expression ; however, betaFGF up-regulated VEGF expression in 99 % of cells but only induced modest changes in Flk-1 overexpression ... At 24 hours, EGF and TGFbeta1 induced a significant increase in both VEGF and Flk-1 expression
Liu et al., Free Radic Biol Med 2006 (Neovascularization, Pathologic) : Reactive oxygen species regulate epidermal growth factor induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells ... The inhibition of H ( 2 ) O ( 2 ) production by catalase abolished EGF induced AKT and p70S6K1 activation, and VEGF expression through HIF-1alpha expression ... This study demonstrates a novel mechanism of EGF induced VEGF and HIF-1alpha expression through production of H2O2 and activation of AKT and p70S6K1 in human ovarian cancer cells
Lang et al., Mol Cancer Ther 2007 (Neovascularization, Pathologic...) : With respect to regulation of angiogenic molecules, 17-AAG significantly reduced EGF mediated VEGF secretion
Schiefelbein et al., J Biol Chem 2008 : Insulin-, but not EGF mediated VEGF protein expression was functionally connected to co-induced HMGR activity, as simvastatin restrictively interfered only with insulin induced translation of VEGF mRNA by inhibition of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) phosphorylation
Rudnicki et al., Lab Invest 2009 (Kidney Diseases...) : In vitro experiments confirmed the positive regulatory effect of EGF and IGF-1 on VEGF-A transcription in human proximal tubular cells
Abounader et al., Expert Rev Anticancer Ther 2009 (Glioma) : Loss of the tumor-suppressor PTEN and activation of the receptor tyrosine kinases ( RTKs ) EGF receptor, c-Met, PDGF receptor and VEGF receptor are among the most common molecular dysfunctions associated with glioma malignancy
Cascio et al., J Cell Physiol 2009 (Colorectal Neoplasms) : Here we investigated the molecular mechanism by which leptin and VEGF expression are regulated in colon cancer by epidermal growth factor (EGF)
Luangdilok et al., Eur J Cancer 2011 (Carcinoma, Squamous Cell...) : Inhibition of p38 MAPK suppressed EGF induced VEGF-C upregulation in CAL 27 cells, but inhibited EGF induced VEGF-A upregulation in Detroit 562
Koochekpour et al., Oncol Rep 1995 : In this study, we investigated the role of basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) , and platelet derived growth factors ( PDGF ) on VEGF production by four different glioma cell lines in vitro
Park et al., Br J Nutr 2013 (Neoplasm Invasiveness...) : Maslinic acid significantly ( P < 0·05 ) down-regulated both basal and EGF stimulated secretion of matrix metalloproteinase (MMP)-9 ( 25-67 % ), MMP-2 ( 50-86 % ), urokinase-type plasminogen activator ( uPA, about 100 % ), vascular endothelial growth factor ( VEGF, 98-100 % ) and tissue inhibitors of metalloproteinases ( TIMP ) -1, as well as expression of uPA receptor (uPAR), intercellular adhesion molecules ( 22-33 % ), vascular cell adhesion molecules ( 23-46 % ) and E-cadherin, whereas it increased TIMP-2 secretion
Shin et al., PloS one 2013 (Neovascularization, Pathologic...) : It also blocked the EGF induced DNA binding activity of HIF-1a and the secretion of the vascular endothelial growth factor ( VEGF ) ... MEL specifically suppressed EGF induced VEGF secretion and new blood vessel formation by inhibiting HIF-1a
Detmar et al., J Invest Dermatol 1995 : Transforming growth factor-alpha, epidermal growth factor , and phorbol myristate acetate markedly stimulated VPF/VEGF mRNA expression by cultured keratinocytes ; as in psoriatic skin, the three most common VPF/VEGF isoforms ( encoding proteins of 121, 165, and 189 amino acids ) were upregulated to an equal extent ... Transforming growth factor ( TGF ) -alpha, epidermal growth factor , and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes ; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion
Goldman et al., Mol Biol Cell 1993 (Brain Neoplasms...) : In vitro experiments with glioma cell lines revealed a consistent and reliable relation between EGFr activation and VEGF production ; namely, EGF ( 1-20 ng/ml ) stimulation of glioma cells resulted in a 25-125 % increase in secretion of bioactive VEGF ... Specifically, EGF activation of EGFr expressed on glioma cells leads to enhanced secretion of VEGF by glioma cells