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CEBPZ — IL6

Text-mined interactions from Literome

Mann et al., J Biol Chem 2002 : CD40 induces interleukin-6 gene transcription in dendritic cells : regulation by TRAF2, AP-1, NF-kappa B, AND CBF1 ... Overexpression of CBF1 resulted in a profound inhibition of basal and anti-CD40 induced IL-6 promoter activities indicating that prolonged induction of CBF1 may contribute to the transient nature of the IL-6 response
Miyazawa et al., Am J Pathol 1998 (Arthritis, Rheumatoid...) : Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes : spontaneous activation of NF-kappaB and CBF1 ... Electrophoretic mobility shift assays revealed that the binding activity of p50 and p65 NF-kappaB subunits and CBF1 was significantly enhanced in the IL-6 high producing clones compared with that of IL-6 low producing clones and cultured sarcoma cells, suggesting that spontaneous activation of NF-kappaB and CBF1 may lead to the constitutive transcription of the IL-6 gene by rheumatoid FLSs