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IL6 — SOCS1
Text-mined interactions from Literome
Dickensheets et al., Proc Natl Acad Sci U S A 1999
(Translocation, Genetic) :
Forced expression of
SOCS-1 in a macrophage cell line, RAW264, markedly
suppressed trans-activation of an IL-4-inducible reporter as well as
IL-6- and IFN-gamma induced reporter gene activity
Diehl et al., Immunity 2000
:
IL-6 upregulates
suppressor of cytokine signaling 1 ( SOCS1 ) expression in activated CD4+ T cells, thereby interfering with signal transducer and activator of transcription 1 ( STAT1 ) phosphorylation induced by interferon gamma (IFNgamma)
Li et al., J Invest Dermatol 2004
(Carcinoma in Situ...) :
To check whether suppressors of cytokine signalling ( SOCS ) play a role in cytokine resistance and tumor progression of melanoma, we investigated the expression and regulation of
SOCS-1 , an established negative
regulator of
interleukin-6 (IL-6) and interferon ( IFN ) signalling ... Both
IL-6 and alpha-IFN
induced rapid and transient
SOCS-1 mRNA expression in WM35 and WM9 melanoma cells
Kimura et al., Proc Natl Acad Sci U S A 2005
:
In this study, we demonstrate that
SOCS-1 selectively
inhibits LPS induced
IL-6 production through regulation of JAK-STAT but not production of TNF-alpha, granulocyte colony stimulating factor, IFN-beta, and other cytokines
Lee et al., Mol Cancer Ther 2006
(Carcinoma, Squamous Cell...) :
Suppressor of cytokine signaling-1 ( SOCS-1 ) has been implicated recently in the negative regulation of IL-6R/Janus activated kinase ( JAK ) -mediated activation of STAT3, suggesting that
SOCS-1 could
affect alternative activation of STAT3 by EGFR,
IL-6R , and associated kinases ... We investigated whether epigenetic modification of
SOCS-1 affects STAT3 activation in
response to
IL-6R- , EGFR-, JAK-, or mitogen activated protein kinase/extracellular signal regulated kinase kinase ( MEK ) -mediated signal activation
Kolliputi et al., Am J Respir Cell Mol Biol 2009
(Acute Lung Injury...) :
Both
IL-6 stimulated endogenous
SOCS-1 and SOCS-1 overexpression abolished H ( 2 ) O ( 2 ) -induced ASK-1 activation
Prêle et al., J Immunol 2008
:
In addition,
SOCS1 regulated the production of
IL-6 , but not IL-10, by monocytes
Neuwirt et al., Am J Pathol 2009
(Neoplasm Recurrence, Local...) :
In LNCaP-interleukin-6- prostate cancer cells,
SOCS-1 was
up-regulated by
interleukin-6 and in PC3-AR cells by androgens ; such up-regulation was also found to significantly impair cell proliferation
Görgün et al., Blood 2010
(Multiple Myeloma) :
SOCS1 negatively
regulates IL-6 signaling and is silenced by hypermethylation in MM cells
Shackleford et al., Breast Cancer Res 2011
(Breast Neoplasms) :
We also analyzed whether the siRNA mediated inactivation of Stat3 and Src could reduce
Jab1-promoter activity and whether
interleukine-6 (IL-6) could
mediate increased Jab1 expression through Stat3 signaling
Park et al., J Allergy Clin Immunol 2013
(Nasal Polyps...) :
Nasal epithelial cell culture was used to elucidate the
effect of IL-4, IL-5,
IL-6 , IL-10, IL-13, IFN-?, TNF-a, and TGF-ß1 on
SOCS1 and SOCS3 expression in sinus mucosa
Suzuki et al., Oncogene 1998
(Leukemia, Myeloid, Acute) :
In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma), while
JAB was
induced strongly by IFNgamma and slightly by
IL6 and leukemia inhibitory factor (ILF)
Nicholson et al., EMBO J 1999
:
SOCS-1 and SOCS-3
inhibited both
interleukin-6 (IL-6)- and leukemia inhibitory factor (LIF) induced macrophage differentiation of murine monocytic leukemic M1 cells and LIF induction of a Stat3-responsive reporter construct in 293T fibroblasts