Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
INSR
→
Complex of ITGAV-ITGB3
(increases, ITGAV/ITGB3 Activity, INSR Activity)
Soldi et al., EMBO J 1999 Evidence: Therefore, avb3 associates with the tyrosine-phosphorylated PDGF and insulin receptor (Vuori and Ruoslahti, 1994; Rousseau et al., 1997) and its natural ligand vitronectin enhances the biological activity of PDGF-b (Schneller et al., 1997;Woodard et al., 1998).
OpenBEL Selventa BEL large corpus:
INSR
→
Complex of ITGAV-ITGB3
(increases, ITGAV/ITGB3 Activity, INSR Activity)
Giancotti et al., Science 1999 Evidence: The receptors for insulin, plateletderived growth factor (PDGF), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) are optimally activated by their ligands only under appropriate cell attachment conditions (24-28). Although a systematic analysis has not been conducted, certain integrins appear to be preferentially associated with specific growth factor receptors. Thus, the avb3 integrin can be immunoprecipitated in complexes with the insulin, PDGF, and VEGF receptors (...