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EPHB2 — HIF1A
Text-mined interactions from Literome
Fukuda et al., Cancer Res 2003
(Colonic Neoplasms) :
Pharmacologic inhibition of
ERK phosphorylation
blocks the induction of VEGF mRNA and
HIF-1alpha protein expression in response to PGE ( 2 ) stimulation
Roy et al., Surgery 2003
(Anoxia...) :
( 1 ) Morphine inhibits hypoxia induced VEGF transcription, in part, through an HIF-1alpha mediated mechanism and ( 2 ) morphine inhibition of hypoxia induced
HIF-1alpha may be
mediated by inhibition of
ERK 1,2 MAP kinase activity and PI3 kinase activity
Liu et al., Biochem Biophys Res Commun 2003
(Anoxia...) :
In a variety of cell lines, the phosphorylation of
HIF-1alpha is
dependent on
ERK or p38, two members of the mitogen activated protein kinase ( MAPK ) superfamily
Wang et al., J Biol Chem 2004
(Neovascularization, Pathologic) :
Ras induction of superoxide activates
ERK dependent angiogenic transcription factor
HIF-1alpha and VEGF-A expression in shock wave stimulated osteoblasts ... Here, we found that SW elevation of VEGF-A expression in human osteoblasts to be mediated by Ras induced superoxide and
ERK dependent
HIF-1alpha activation ... In support of the observation that superoxide mediated the SW-induced
ERK activation and
HIF-1alpha transactivation , we further demonstrated that scavenging of superoxide by superoxide dismutase and inhibition of ERK activity by PD98059 decreased HIF-1alpha activation and VEGF-A levels
Pi et al., Circ Res 2005
:
Hypoxia inducible factor 1alpha ( HIF1alpha ), a potent mediator of angiogenesis, is positively
regulated by the MAP kinases,
ERK1/2
Dimova et al., Thromb Haemost 2005
(MAP Kinase Signaling System...) :
Thus, IGF-1 activates human PAI-1 gene expression through
activation of the PI3-kinase and
ERK1/2 via
HIF-1alpha
Zhang et al., Exp Cell Res 2006
(Keloid) :
Our results also indicated that the enhancement of hypoxia mediated activation of ERK1/2 and Akt requires direct cell-cell interaction between mast cells and keloid fibroblasts, and activation of both
ERK1/2 and Akt is
involved in the hypoxia dependent
HIF-1alpha protein accumulation and VEGF expression in the co-culture system
Oh et al., Cancer Lett 2008
(Uterine Cervical Neoplasms) :
PD98059,
ERK inhibitor
reduced HIF-1 alpha increased by TB4P
Bove et al., J Biol Chem 2008
(Inflammation) :
Collectively, our results demonstrate that inflammatory levels of NO inhibit epithelial cell migration, because of suppression of
ERK1/2 signaling, and
activation of
HIF-1alpha and p53, with potential consequences for epithelial repair and remodeling during airway inflammation
Bartella et al., Cancer Res 2008
(Breast Neoplasms) :
Using MDA-MB-231 breast cancer cells, we found that ( a ) insulin stimulated leptin mRNA and protein expression, which was associated with increased activation of the leptin gene promoter ; ( b ) insulin increased nuclear accumulation of transcription factors hypoxia inducible factor (HIF)-1alpha and Sp1 and their loading on the leptin promoter ; ( c ) small interfering RNA ( siRNA ) -mediated knockdown of either HIF-1alpha or Sp1 significantly down-regulated insulin induced leptin mRNA and protein expression ; further inhibition of leptin expression was observed under the combined HIF-1alpha and Sp1 siRNA treatment ; ( d ) inhibition of extracellular signal regulated kinase ( ERK ) 1/2 and phosphatidylinositol-3-OH kinase (PI-3K) pathways significantly, albeit partially, decreased insulin dependent leptin mRNA and protein expression, which coincided with reduced association of HIF-1alpha and/or Sp1 with specific leptin promoter regions ; and ( e ) inhibition of
ERK1/2 reduced recruitment of both HIF-1alpha and Sp1 to the leptin promoter, whereas down-regulation of PI-3K influenced only
HIF-1alpha binding
Yang et al., Invest Ophthalmol Vis Sci 2009
(Anoxia...) :
Role of PI3K/Akt and
MEK/ERK in mediating hypoxia induced expression of
HIF-1alpha and VEGF in laser induced rat choroidal neovascularization
Mori et al., Mol Cancer Res 2009
(Pancreatic Neoplasms) :
In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by
KRAS/Raf/MAPK/Erk signaling, but
involves the IL-1beta/IL-1R system, p38, and the transcription factor
HIF-1alpha
Sumbayev et al., Eur J Immunol 2009
:
ERK and p38 MAPK, but not reactive oxygen species ( ROS ), ASK1 or PI 3-kinase, were
critical for IgE mediated accumulation of
HIF-1alpha , although the latter crucially affected degranulation
Westra et al., BMC musculoskeletal disorders 2010
(Arthritis...) :
HIF-1 alpha protein expression in LPS stimulated THP-1 macrophages could be
blocked by
ERK- and PI3K-inhibitors, but also by the CaMKII inhibitor KN93 ... Expression of
HIF-1 alpha and downstream effects in macrophages are
regulated by
ERK- , PI3K, but also by CaMKII pathways
Fu et al., BMC cell biology 2010
(Anoxia) :
The hypoxia induced
HIF-1alpha activation, reactive oxygen species ( ROS ) generation and
ERK activation might be
involved in this response