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APP — NOTCH1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: APP — NOTCH1 (physical association, affinity chromatography technology) Kim et al., Biochim Biophys Acta 2007*
• Gene Ontology Complexes receptor complex: receptor complex complex (PTH1R-TAOK2-VLDLR-TGFBR2-GABRG1-KCTD8-EGFR-RET-NTRK1-RIPK1-INSR-TRPC1-INSRR-GABRA5-FLT4-ADCYAP1R1-GPR37-P2RX2-LOXL4-IMPG2-PKD1L3-NOTCH1-ADRA2A-TRADD-LRP2-MTTP-GPR101-ITLN1-VIPR1-CD200R1-GRM7-GPR84-FCRL5-RNMT-ITGB1-NPR1-SLITRK5-IL4R-KCTD12-PLA2R1-RAMP1-RXRA-RAMP2-PIGR-GPR62-GPR63-GPR61-ITPR3-GPR20-MTNR1A-ROR1-ABCG5-CR2-GPR37L1-LRP1-LRP6-KCTD16-LRP5-CR1L-NTRK2-APP-GABRQ-CSF1-ABCG8-ADRB2-ADRB3-TLR7-GPR119-TAS1R2) Roka et al., Mol Pharmacol 1999, Small et al., J Biol Chem 2000, Graf et al., J Biol Chem 2003, Breit et al., J Biol Chem 2004, Bomberger et al., J Biol Chem 2005, Turunen et al., Nucleic Acids Res 2007, Ding et al., J Cell Biol 2008, Ghai et al., Proc Natl Acad Sci U S A 2013, Lin et al., J Biol Chem 1995, Hsu et al., Immunity 1996, Zhang et al., Nature 1996

Text-mined interactions from Literome

Berezovska et al., J Neurochem 2000 : We also show that two APP gamma-secretase inhibitors block Notch1 nuclear translocation with an IC ( 50 ) similar to that reported for APP gamma-secretase
Berezovska et al., Ann N Y Acad Sci 2000 (Alzheimer Disease) : Moreover, we show that two APP gamma-secretase inhibitors also diminish Notch1 nuclear translocation in a dose dependent fashion
Kwak et al., Eur J Pharmacol 2011 : These results indicate APP induces glial differentiation of NPCs through Notch signaling