Gene interactions and pathways from curated databases and text-mining

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IRF6 — THBD

Text-mined interactions from Literome

Kume et al., J Hepatol 2003 (Liver Diseases...) : To elucidate the mechanism of liver dysfunction occurring in patients with sepsis, we evaluated the effect of bacterial lipopolysaccharide (LPS) on the expression of thrombomodulin (TM) in rat sinusoidal endothelial cells ( SECs ) and the therapeutic efficacy of exogenous recombinant TM
Verbon et al., J Infect Dis 2003 (Endotoxemia) : Furthermore, LPS reduced thrombin-activatable fibrinolysis-inhibitor antigen levels and increased soluble thrombomodulin levels, which were not influenced by IC14
Gao et al., J Nat Med 2009 (Sepsis) : In vitro, SAM reversed the decreased expressions of thrombomodulin (TM) and endothelial PC receptor ( EPCR ) mRNA induced by lipopolysaccharide (LPS) in endothelial cells
Herbert et al., FEBS Lett 1993 : When measured in parallel, IL-4 and IL-13 counteracted thrombomodulin down-regulation induced by LPS , IL-1 or TNF in endothelial cells