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AXIN2 — TP53

Text-mined interactions from Literome

Rui et al., EMBO J 2004 : Axin , but not AxindeltaHIPK2, activates HIPK2 mediated p53 phosphorylation at Ser 46, facilitating p53 dependent transcriptional activity and apoptosis
Frappart et al., EMBO J 2007 (Medulloblastoma) : These neurological defects arose from DNA damage as Brca2 ( LoxP/LoxP ) ; Nestin-cre mice showed extensive gammaH2AX in neural tissue and p53 deficiency restored brain histology but lead to rapid formation of medulloblastoma brain tumors
Tseng et al., Oncogene 2008 (Carcinoma, Non-Small-Cell Lung...) : Therefore, we postulated that alteration of the degradation complex AXIN2 ( axis inhibition protein 2 ) and betaTrCP ( beta-transducin repeat containing protein ) and p53 regulation could result in beta-catenin protein accumulation in lung cancer
Li et al., Oncogene 2011 : Moreover, we found that dominant negative mutants of PML blocked AXIN induced p53 activation, and that AXIN promotes PML sumoylation, a modification necessary for PML functions
Atsumi et al., PloS one 2011 (Genomic Instability...) : Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells
Lu et al., Oncol Rep 2013 (Glioma) : In addition, ectopic expression of Axin by transient transfection of C6 cells with rAxin revealed that overexpression of Axin induced cell cycle arrest and apoptosis with an upregulation of p53