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CASP9 — EPO

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Chong et al., Circulation 2002 : Subsequently, EPO inhibited caspase 8-, caspase 1-, and caspase 3-like activities that were linked to mitochondrial cytochrome c release
Chong et al., J Neurosci Res 2003 : Subsequently, EPO inhibits caspase 8-, caspase 1-, and caspase 3-like activities linked to cytochrome c release through mechanisms that are independent from the MAP kinase systems of p38 and JNK
Abdelrahman et al., Shock 2004 (Disease Models, Animal...) : In cultured human proximal tubule cells, EPO concentration-dependently reduced the cell death and increase in caspase-3 activity caused by either ATP depletion ( simulated ischemia ) or hydrogen peroxide ( oxidative stress )
Fukuda et al., Cell Death Differ 2004 (Body Weight) : Irradiation induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition
Sharples et al., J Am Soc Nephrol 2004 (Disease Models, Animal...) : Specifically, EPO ( 300 U/kg ) reduced glomerular dysfunction and tubular injury ( biochemical and histologic assessment ) and prevented caspase-3 , -8, and -9 activation in vivo and reduced apoptotic cell death ... EPO reduced DNA fragmentation and prevented caspase-3 activation, with upregulation of Bcl-X ( L ) and XIAP
Sekiguchi et al., Biochem Biophys Res Commun 2005 : In parallel, exposure to high glucose level induced caspase-3 activation and erythropoietin also prevented it ... PI3 kinase inhibitor, wortmannin or LY294002 eliminated erythropoietin 's inhibitory effect on caspase-3 activity
Lui et al., FEBS Lett 2006 : Erythropoietin activates caspase-3 and downregulates CAD during erythroid differentiation in TF-1 cells - a protection mechanism against DNA fragmentation
Lee et al., J Neurochem 2006 (Brain Edema...) : In addition, EPO reduced the mRNA level of TNF-alpha, Fas and Fas-L, as well as the activities of caspase-8 , 9 and 3
Nishiya et al., J Pharmacol Sci 2006 (Disease Models, Animal...) : Five days after MI, EPO prevented the increase in activated caspase 3, matrix metalloproteinase-2, and transcriptional activation of activator protein-1 in non infarcted myocardium
Wu et al., Apoptosis 2007 : The effects of EPO on GSK-3beta and caspase-3 activities were also blocked by LY294002
Ranchon Cole et al., Exp Eye Res 2007 (Radiation Injuries...) : In parallel, we tested Epo protection against oxidative stressors on isolated retinas and its effect on caspase-9 activity ... Epo injected at 30,000U/kg body weight, 4h before exposure to the damaging light, protected retinal function and structure against light damage and induced an increase in caspase-9 activity and expression
Bürgers et al., Exp Brain Res 2008 (Hypoxia-Ischemia, Brain...) : Erythropoietin reduced total caspase activity by nearly 30 % under all the conditions, whereas caspase 3/7 activity was not affected
Wang et al., Eur J Pharmacol 2008 : Studies on the apoptotic signaling showed that recombinant human erythropoietin inhibited the activation of caspase-3 and upregulated the expression of anti-apoptotic gene, Bcl-XL
Wang et al., Free Radic Biol Med 2009 (Macular Degeneration) : EPO inhibited caspase-3-like activity
Wang et al., Nan Fang Yi Ke Da Xue Xue Bao 2010 (Status Epilepticus) : [ Effect of recombinant human erythropoietin on hippocampal p-Akt and caspase-9 expressions in rats with status epilepticus and the mechanism ] ... To observe the effect of recombinant human erythropoietin ( rhuEPO ) on p-Akt and caspase-9 expressions in the hippocampus of rats with status epilepticus ( SE ) and explore the neuroprotective mechanism of rhuEPO
Diaz et al., Biol Reprod 2011 : CASP3 mRNA was increased ( P < 0.01 ) by EPO ( 3.4-fold ) and by PGF ( 2.7-fold ) but was most dramatically increased by PGF+EPO ( 5.3-fold ), whereas caspase activity was only increased by PGF ( 1.5-fold ) or PGF+EPO ( 2.2-fold )
Ge et al., Neurol Sci 2012 : Finally, TDZD-8 and EPO significantly suppressed the enhanced apoptosis and activity of caspase 3 induced by 6-OHDA