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MAP4K4 — TNF
Pathways - manually collected, often from reviews:
-
BioCarta nf-kb signaling pathway:
TNF/TNF R/FADD/TRADD/RIP/TRAF6 complex (TNF-TNFRSF1A-FADD-TRADD-RIPK1-TRAF6)
→
IKK-alpha/MEKK1/NIK complex (CHUK-MAP3K1-MAP4K4)
(modification, activates)
Text-mined interactions from Literome
Tang et al., Proc Natl Acad Sci U S A 2006
:
Furthermore,
TNF-alpha signaling to down-regulate GLUT4 is
impaired in the absence of
MAP4K4/NIK , indicating that MAP4K4 expression is required for optimal TNF-alpha action
Tesz et al., J Biol Chem 2007
(Inflammation...) :
TNFalpha signaling decreases peroxisome proliferator activated receptor gamma and glucose transporter isoform 4 (GLUT4) expression in adipocytes, impairing insulin action, and this is
mediated in part by the yeast Ste20 protein kinase ortholog
Map4k4 ... Here we show that
Map4k4 expression is selectively
up-regulated by
TNFalpha , whereas the expression of the protein kinases JNK1/2, ERK1/2, p38 stress activated protein kinase, and mitogen activated protein kinase kinases 4/7 shows little or no response
Ait-Lounis et al., PLoS Negl Trop Dis 2012
(Disease Models, Animal...) :
Our findings suggest that Aah venom induces insulin resistance by mechanisms involving
TNF-a dependent
Map4k4 kinase activation in the adipose tissue