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MMP2 — TNF

Text-mined interactions from Literome

Gallery et al., Microvasc Res 1999 (Pre-Eclampsia...) : Neither tumor necrosis factor-alpha nor transforming growth factor-beta, both thought to have significant roles in the control of placentation, affected MMP secretion
Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF) , interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Watari et al., Am J Pathol 1999 : TNF-alpha induced cathepsin S, MMP-1 , -3, and -9 mRNA expression in a dose dependent manner : the maximal effect was observed at a concentration of 10 ng/ml, with appreciable increases observed at concentrations of 0.1 to 1.0 ng/ml
Conant et al., Ann Neurol 1999 (AIDS Dementia Complex) : We also examined the possibility that such MMPs could be produced by brain derived cells, and that MMP production by these cells might be increased by tumor necrosis factor-alpha , an inflammatory cytokine that is produced by HIV infected monocytes/microglia and is elevated in HIVD
Nakada-Tsukui et al., J Leukoc Biol 1999 : Although only hydroxamate matrix metalloproteinase ( MMP ) inhibitors inhibited the basal processing and release of TNF-alpha , the PMA induced processing and release of TNF-alpha were inhibited not only by MMP inhibitors but also by 1,10-phenanthroline, 3,4-dichloroisocoumarin ( 3,4-DCI ), iodoacetamide, and Nalpha-p-tosyl-L-phenylalanine chloromethyl ketone ( TPCK )
Chambaut-Guérin et al., J Neurochem 2000 (Neuroblastoma) : In contrast, MMP-9 was inducible by RA, TNFalpha , or PMA
Siwik et al., Circ Res 2000 : IL-1beta and TNF-alpha each increased total matrix metalloproteinase ( MMP ) activity as measured by in-gel zymography, causing specific increases in the bands corresponding to MMP-13, MMP-2, and MMP-9
Lee et al., Endocrinology 2000 : Using a primary culture model in which rat MEC grow three-dimensionally within a reconstituted basement membrane, we found that TNF stimulated secretion of MMP-9 but not MMP-2
Han et al., J Cell Sci 2001 : To investigate this observation at the cellular and molecular levels, we examined TNF-(alpha) mediated activation of pro-MMP-2, induction of MT1-MMP , and the intracellular signaling pathways that regulate the proteinase in isolated human dermal fibroblasts ... We found that TNF-(alpha) substantially promoted activation of pro-MMP-2 in dermal fibroblasts embedded in type-I collagen ... Based on these results and previous reports, we propose a model to explain TNF-(alpha) activation of MMP-2 in human skin
Schweyer et al., Virchows Arch 2000 (Gout) : These macrophages co-produce the proinflammatory cytokine TNF-alpha and two TNF-alpha inducible lytic enzymes, MMP-2 and MMP-9, suggesting that TNF-alpha may induce MMP production followed by matrix degradation within foreign body granulomas
Gottsch et al., Reprod Fertil Dev 2000 : The objective of this investigation was to ascertain the regulatory role of TNFalpha on MMP-2 activity relevant to the folliculo-luteal transition in ewes
Ueda et al., J Endod 2001 : TNF-alpha stimulated MMP-2 activity in conditioned medium and stimulated MMP-9 activity with addition of plasminogen into conditioned medium
Baram et al., J Immunol 2001 : MMP-9 release was first detected at 6 h and peaked at 22 h of incubation with activated T cell membranes, while TNF-alpha release peaked after only 6 h. Anti-TNF-alpha mAb inhibited the T cell membrane induced MMP-9 release, indicating a possible autocrine regulation of MMP release by mast cell TNF-alpha
Miyajima et al., Microb Pathog 2001 (Corneal Ulcer...) : Effects of pseudomonal virulence factors [ elastase, alkaline protease, exotoxin A and lipopolysaccharide (LPS) ], tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta on MMP induction and activation were further examined in vitro in rabbit corneal fibroblasts ( RCF ) and human fibrosarcoma ( HT1080 ) cells using reverse transcriptase-polymerase chain reaction ( RT-PCR ), zymography and immunoblotting
Majka et al., Invest Ophthalmol Vis Sci 2002 (Retinal Neovascularization) : Isolated RMVECs did not significantly increase MMP production directly in response to a hypoxic stimulus, but required the presence of exogenous TNFalpha ... TNFalpha increased the expression of MT1-MMP , MMP-3, and MMP-9 in these cells
Okuno et al., Scand J Gastroenterol 2002 : IL-1beta and TNF-alpha both induced a dose- and time dependent increase in IL-8, MCP-1 and MMP-1 secretion, and weakly stimulated MMP-2 secretion
Limb et al., Am J Pathol 2002 : Tumor necrosis factor-alpha , in both a soluble form or bound to collagen and fibronectin, increased MMP-9 mRNA and gelatinolytic activity, but not MMP-2 expression, and its effect could be blocked by anti-tumor necrosis factor-alpha antibodies
Nishikawa et al., J Periodontal Res 2002 : This study used reverse transcriptase-PCR to investigate the effects of TNFalpha on matrix metalloproteinase ( MMP ) mRNA expression in human periodontal ligament fibroblasts ... TNFalpha increased MMP-1, MMP-3 and MMP-13 mRNA levels in both a time dependent ( 0-24 h ) and a dose dependent ( 0.1-10 ng/ml ) manner ... Because elevation of COX-2 mRNA levels enhances the production of prostaglandins, we therefore investigated whether endogenous prostaglandins are involved in the MMP mRNA expression that is enhanced by TNFalpha
Domeij et al., Eur J Oral Sci 2002 (MAP Kinase Signaling System) : In addition, MMP-1 and MMP-3 production, induced by IL-1beta, TNFalpha or EGF, was strongly reduced by the presence of the glucocorticoid dexamethasone
Abraham et al., Int Immunol 2002 : IL-18 and IL-12 separately and synergistically enhanced MMP-2 , while TNF-alpha led to the elevation of MMP-9
Peng et al., Circ Res 2002 (Cardiomyopathies...) : In cultured neonatal rat cardiac fibroblasts, TNF-alpha reduced cellular [ 3H ] -proline incorporation, increased matrix metalloproteinase-2 (MMP-2) activity and protein, and increased TIMP-1 protein levels
Alexander et al., Invest Ophthalmol Vis Sci 2003 (MAP Kinase Signaling System) : The components of this MAP kinase pathway in the TM are dramatically affected by TNFalpha and inhibition of Erk 's phosphorylation blocks the changes in MMP and TIMP expression
Phillips et al., Gut 2003 : MMP2 secretion by PSCs was significantly increased by TGF-beta1 and IL-6, but was not affected by TNF-alpha
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha) , IL-6, HGF, and 12-O-tetradecanoylphorbol 13-acetate
Kobayashi et al., Acta Derm Venereol 2003 : Moreover, TGF-beta1, TNF-alpha , or epidermal growth factor augmented the secretion of MMP-2 from fibroblasts
Lee et al., J Allergy Clin Immunol 2003 (Asthma...) : These results suggest that MMP inhibitors regulate inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression and possibly also by suppressing IL-1beta, IL-4, and TNF-alpha expression
Bamba et al., J Gastroenterol 2003 : In human colonic SEMFs, MMP-3 secretion and MMP-3 mRNA expression were induced by IL-17, IL-1beta, and TNF-alpha
Wang et al., Cardiovasc Res 2003 : TNF-alpha mediates the stretch induced MMP genes expression, at least in part, through the JNK pathway
Lorenzo et al., Matrix 1992 : In unstimulated osteoblast-like MC3T3-E1 cell cultures 72-kDa gelatinase enzyme activity was much greater than 92-kDa activity and was not substantially regulated ( less than 40 % change ) by IL-1, TNF or PTH
Arenas et al., Am J Physiol Cell Physiol 2004 : Angiotensin II-induced MMP-2 release from endothelial cells is mediated by TNF-alpha ... To elucidate whether endogenous TNF-alpha could mediate the effects of ANG II on MMP-2 release, cells were pretreated with anti-TNF-alpha neutralizing antibodies or pentoxifylline ( an inhibitor of TNF-alpha synthesis ) ... TNF-alpha inhibition prevented the secretion of MMP-2 induced by ANG II ... These results indicate that ANG II, via AT(1)R, modulates the secretion of TNF-alpha and MMP-2 from endothelial cells and that TNF-alpha mediates the effects of ANG II on MMP-2 release
Hui et al., Arthritis Rheum 2003 (Osteoarthritis, Knee) : The in vivo data clearly indicated that OSM + TNFalpha overexpression increased MMP levels and decreased levels of tissue inhibitor of metalloproteinases 1 ( TIMP-1 ) ... Specifically, OSM + TNFalpha induced marked synovial hyperplasia, inflammation, and cartilage and bone destruction with a concomitant increase in MMP expression in both cartilage and synovium and decreased TIMP-1 expression in the articular cartilage
Moon et al., J Cell Physiol 2004 : Finally, the transient transfection of HASMC with dominant negative Ras ( RasN17 ) suppressed TNF-alpha induced ERK activity, MMP-9 production, and promoter activity
Hashizume et al., J Reprod Dev 2003 : Both TNF-alpha and TNF-beta strongly stimulated the production of MMP-2 and MMP-9, whereas IGFs had no effect
Lévêque et al., Microbes Infect 2004 : Differential regulation of gelatinase A and B and TIMP-1 and -2 by TNFalpha and HIV virions in astrocytes
Chen et al., Di Yi Jun Yi Da Xue Xue Bao 2004 : The effect of exogenous TNF-alpha and anti-TNF-alpha on the expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinases-2 ( TIMP-2 ) in human trophoblastic cells was investigated with reverse transcription ( RT ) -PCR ( RT-PCR )
Meli et al., J Neuroimmunol 2004 (Disease Models, Animal...) : We investigated the pharmacokinetics and the effect of TNF484 , a water-soluble hydroxamate based inhibitor of MMP and TACE, on disease parameters and brain damage in a neonatal rat model of pneumococcal meningitis
Martin-Chouly et al., Life Sci 2004 : One hour of pre-incubation with PDE4 inhibitors ( 10 microM ) induced an inhibition of TNF-alpha stimulated pro-MMP-2 release ... These results suggest that PDE4 inhibitors are effective in inhibiting the pro-MMP-2 and pro-MMP-1 secretion induced by TNF-alpha and might underline a potential therapeutic benefit of selective PDE4 inhibitors in lung diseases associated with abnormal tissue remodelling
Churg et al., Am J Respir Crit Care Med 2004 (Pulmonary Emphysema) : TNF-alpha causes increased MMP production, but some increased MMP activity is present even in TNFRKO mice
Dayer et al., Reumatismo 2004 (Arthritis, Rheumatoid) : IL-1 and TNF-alpha are potent inducers of matrix metalloproteinases ( MMP ) , eicosanoids, nitric oxide oxydase ( iNOS ), receptor activator of NF-kB ligand ( RANKL ), products involved in the destruction of the extracellular matrix, the cartilage and in bone resorption
Ha et al., Vascul Pharmacol 2004 : In this study, we investigated the inhibitory effect of CDS on tumor necrosis factor-alpha (TNF-alpha) induced human aortic smooth muscle cells ( HASMC ) migration and MMP-2 and -9 activity
Namba et al., Acta Otolaryngol 2004 (Nasal Polyps) : The addition of FP caused significant suppression of MMP-2 and -9 production from nasal polyp fibroblasts in response to TNF-alpha stimulation
Zhang et al., Mol Reprod Dev 2005 : Matrix metalloproteinase-2 (MMP-2) expression and regulation by tumor necrosis factor alpha (TNFalpha) in the bovine corpus luteum
Kobayashi et al., Arthritis Rheum 2005 (Osteoarthritis, Knee) : Independent analyses of gene expression in cultured cartilage from 9 other OA patients revealed that IL-1 or TNFalpha blockade, either alone and/or in combination, frequently down-regulated MMP-1, MMP-3 , and MMP-13 expression
Bruce et al., Toxicol Appl Pharmacol 2005 (Asthma...) : Tumor necrosis factor alpha (TNFalpha) has been shown to be an important cytokine in the pathogenesis of allergic airway inflammatory responses, and its release can be inhibited by MMP inhibitors
Shimizu et al., Mediators Inflamm 2005 (Rhinitis, Allergic, Perennial) : We evaluated whether tranilast ( TR ) could inhibit MMP production from nasal fibroblasts in response to tumor necrosis factor-alpha (TNF-alpha) stimulation in vitro ... TR at more than 5 x 10 ( -5 ) M inhibited the production of MMP-2 and MMP-9 from NF in response to TNF-alpha stimulation, whereas TIMP-1 and TIMP-2 production was scarcely affected
Krueger et al., J Biol Chem 2006 : In vitro, MMP-1 is up-regulated by interleukin-1beta and tumor necrosis factor-alpha , but these regulatory mechanisms are not operating in H. pylori infection as shown by inhibitory antibodies
Sondergaard et al., Osteoarthritis Cartilage 2006 : TNF-alpha and OSM induced a pronounced increase in matrix metalloproteinase ( MMP ) activity, which was strongly inhibited by calcitonin
Ben-Hur et al., J Neuroimmunol 2006 : NPCs ' gelatinase activities of MMP-2 and MMP-9, as determined by zymography, were increased by TNF-alpha , and to a lesser extent by IFN-gamma ... IFN-beta suppressed the TNF-alpha induced levels of secreted MMP-9 and MMP-2 , while enhancing the expression of TIMP-1 and TIMP-2 mRNA
Roy et al., Antioxid Redox Signal 2006 (Inflammation) : Pretreatment of HMECs for 2 days with BE potently prevented TNFalpha induced expression and activity of MMP-3, MMP-10 , and MMP-12
Chung et al., Curr Drug Targets 2006 (Pulmonary Disease, Chronic Obstructive) : TNFalpha and IL-1beta stimulate macrophages to produce matrix metalloproteinase-9 [ MMP-9 ], and bronchial epithelial cells to produce extracellular matrix glycoproteins
Yamada et al., Arch Virol 2006 : After infection, TNF-alpha mRNA levels increased rapidly to a peak on day one, and then trypsin I and matrix metalloproteinase (MMP)-9, but not MMP-2 , were significantly up-regulated with a peak on day 2 in vivo
Shen et al., Biochem Biophys Res Commun 2006 : However, TNFalpha blockade ( neutralizing antibodies against human TNFalpha, 25 microg/ml ) significantly reduced the activity of MMP-2 and markers of apoptosis induced by TNFalpha
Fushimi et al., J Cell Biochem 2007 (MAP Kinase Signaling System) : In response to TNF-alpha , MMP-1 is induced and actively released from HCS-2/8 cells
Lin et al., Nan Fang Yi Ke Da Xue Xue Bao 2006 : To investigate the regulatory effects of fenofibrate on TNF-alpha induced CD40 expression and matrix metalloproteinase ( MMP ) activity in human vascular endothelial cells ( HUVECs ) ... Fenofibrate significantly inhibited the stimulatory effect of TNF-alpha on MMP-2 and MMP-9 activities in HUVECs ... Fenofibrate reduces TNF-alpha induced increment of CD40 expression and MMP-2 and MMP-9 activities in HUVECs
Inatomi et al., Pancreas 2007 : In human pancreatic myofibroblasts, MMP-3 secretion and mRNA expression were induced by interleukin (IL)-17, IL-1beta, and tumor necrosis factor (TNF) -alpha, respectively
Zeni et al., Am J Physiol Cell Physiol 2007 : Moreover, MMP activity in PCPEC supernatants was significantly increased by TNF-alpha , presumably due to a diminished expression of TIMP-3 that was similarly observed
Yagi et al., J Gastroenterol 2007 (Colitis) : A similar augmentation was also observed in tumor necrosis factor (TNF)-alpha induced cytokine and MMP secretion
Gamo et al., J Exp Zool A Ecol Genet Physiol 2007 : The effects of TNF-alpha on proliferation and MMP production of RES have been shown for the first time
Wu et al., Free Radic Biol Med 2007 (Atherosclerosis...) : Besides, pretreatment with carvedilol or probucol but not propranolol, a beta-blocker, or prazocin, an alpha-blocker, inhibited tumor necrosis factor-alpha stimulated expressions and activities of MMP-2 and MMP-9 in human aortic smooth muscle cells
Lockwood et al., Biol Reprod 2008 (Pre-Eclampsia) : Similarly, quantitative RT-PCR found that TNF and IL1B enhanced MMP9, but not MMP2 , mRNA levels
Séguin et al., Spine (Phila Pa 1976) 2008 : TNF-alpha induces MMP2 gelatinase activity and MT1-MMP expression in an in vitro model of nucleus pulposus tissue degeneration ... The effect of TNF-alpha on membrane type (MT)1-MMP , an activator of MMP-2, was also assessed ... TNF-alpha treatment induced MMP-2 gelatinase activity, which occurred in the absence of any change in MMP-2 gene or protein expression, but did correlate with increased MT1-MMP mRNA and protein levels ... As ERK also appeared to regulate MT1-MMP production, this suggests that TNF-alpha induction of MMP-2 gelatinase activity may be regulated by MT1-MMP
Rogliani et al., Respir Med 2008 (Pulmonary Emphysema...) : In contrast, fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2, MMP-9 , MMP-7 and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects, in the presence of similar levels of TIMP-1, TIMP-2 and TNF-alpha ... In contrast, fibroblasts in areas of parenchymal destruction of emphysema/UIP expressed MMP-2 , MMP-9, MMP-7 and MT1-MMP at variable but significantly higher levels when compared to emphysema subjects, in the presence of similar levels of TIMP-1, TIMP-2 and TNF-alpha
Müller et al., Cytokine 2008 : TNF-alpha suppressed collagen type II and aggrecan, but increased MMP and cytokine expression in chondrocytes compared to the non stimulated controls
Yao et al., Biol Reprod 2009 : In primary cocultures, MEHP exposure causes a 9.46-fold increase in sTNFA, while the addition of recombinant MMP2 protein results in a 5.4-fold increase in sTNFA, suggesting that MEHP induced MMP2 is in part responsible for the activation of TNFA in the testis
Asano et al., Int J Chron Obstruct Pulmon Dis 2008 : We evaluated whether tiotropium bromide hydrate ( TBH ), a M3 muscarinic receptor antagonist, could inhibit MMP production from lung fibroblasts ( LFs ) in response to tumor necrosis factor (TNF)-alpha stimulation
Millward-Sadler et al., Arthritis Res Ther 2009 (Intervertebral Disc Degeneration) : TNF-alpha does not induce MMP expression to the same degree as stimulation by IL-1beta, but it does act to upregulate IL-1beta expression as well as TNF-alpha and TNF-R2
Lee et al., J Nat Med 2009 : Gelatin zymography results showed that pretreatment with EGE to human umbilical vein endothelial cells ( HUVEC ) decreased TNF-alpha induced increase of matrix metalloproteinase (MMP)-2/-9 activities in the range of 1-50 microg/ml. Real-time qRT-PCR results also revealed that TNF-alpha induced MMP-2/-9 mRNA expression levels were attenuated by pretreatment with EGE
Steenport et al., J Immunol 2009 (Chronic Disease...) : Exposure of macrophages to MMP-1 and MMP-3 triggered the rapid release of TNF-alpha , which was blocked by MMP inhibitors
Awad et al., Am J Physiol Cell Physiol 2010 (Cardiomyopathies...) : TNF did not induce MMP2 expression ... We identified phosphatidylinositol 3-kinase (PI3K)gamma as a key factor in TNF mediated events since TNF induced superoxide production, MMP expression, and activity were significantly suppressed in cardiomyocytes and cardiofibroblasts deficient in PI3Kgamma
Oliveira et al., J Neuropathol Exp Neurol 2010 (Leprosy...) : Mycobacterium leprae and TNF induced upregulation of MMP-2 and MMP-9 and increased secretion of these enzymes in cultured ST88-14 cells
Kim et al., Nutrition research and practice 2007 : The MMP-2 gelatinolytic activity of endothelial cells was enhanced by TNF-alpha , which was attenuated by an addition of > /=25 microM resveratrol
Murray et al., J Mol Cell Cardiol 2010 : While we have previously shown a role for cardiac mast cells in mediating increases in myocardial TNF-alpha, however, matrix metalloproteinase ( MMP ) activation of TNF-alpha may also be contributory
Lee et al., J Immunol 2010 : Notably, MMP-8 inhibitor suppressed TNF-alpha production more efficaciously than MMP-3 or MMP-9 inhibitors
Scian et al., Infect Immun 2011 : Supernatants from B. abortus infected monocytes induced MMP-2 secretion in uninfected osteoblasts, and this effect was mediated by TNF-a
Xu et al., Placenta 2011 : In conclusion, TNF-a can inhibit trophoblast-like cells ( JEG-3 ) integration into maternal endothelial cellular networks, and this process involves the inhibition of MMP-2 and a failure of integrins switch from a ( 6 ) ß ( 4 ) to a ( 1 ) ß ( 1. )
Ye et al., Wound Repair Regen 2011 : It has been reported that tumor necrosis factor-a (TNF-a) induces the production of matrix metalloproteinase-2 (MMP-2) and transforming growth factor-ß1 ( TGF-ß1 ) in fibroblasts ... In this study, we demonstrated that the active MMP-2 secreted by lung fibroblasts reached the peak level at 12 hours after TNF-a treatment, whereas, by adding anti-TGF-ß1 antibody in the culture medium, the MMP-2 production in response to TNF-a was maintained at high levels after 24 hours of treatment ... We also confirmed that TNF-a induced up-regulation of active TGF-ß1 and exogenous TGF-ß1 induced down-regulation of MMP-2 synthesis in lung fibroblasts ... Taken together, our results demonstrate that TNF-a induced an increase of MMP-2 and TGF-ß1 in lung fibroblasts, and the TGF-ß1 attenuated the up-regulation of MMP-2
Park et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011 : MMP inhibitors, such as doxycycline, minocycline, and batimastat, significantly reduced the cerebral infarct size, and the expressions of monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-a (TNF-a) , and indoleamine 2,3-dioxygenase (IDO)
Zhang et al., Inflammation 2012 (Arthritis, Rheumatoid...) : IL-1ß or TNF-a increased expression of MMP-9 and MMP-2 in rheumatoid synoviocytes ; EGF stimulated expression of MMP-9 but not of MMP-2 ; genistein suppressed production of MMP-9 more than MMP-2 induced by IL-1ß or TNF-a ; rMMP-9, rMMP-2, or their inhibitors had no effect on the ( 3 ) H-TdR incorporation of synovial cells ... Neither PD098059 nor SP600 125 could inhibit the MMP-2 expression induced by TNF-a or IL-1ß
Lin et al., J Pharm Pharmacol 2011 (Atherosclerosis...) : Monascus purpureus fermented rice inhibits tumor necrosis factor-a induced upregulation of matrix metalloproteinase 2 and 9 in human aortic smooth muscle cells ... RT-PCR and immunoblot analyses show that Cholestin extract significantly attenuates TNF-a induced mRNA and protein expressions of MMP-2 and MMP-9 ... Cholestin reduces TNF-a stimulated MMP-2 and MMP-9 expression as well as downregulating NF-?B activation and intracellular ROS formation in HASMCs, supporting the notion that the natural compound Cholestin may have potential application in clinical atherosclerosis disease
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1, MMP-2 and MMP-3, and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Wang et al., Zhonghua Yan Ke Za Zhi 2011 : To investigate the effect of focal adhesional kinase ( FAK ) on tumor necrosis factor a (TNF-a) induced MMP-2 and -9 activities in cornea epithelium ... After down regulating the protein FAK, TNF-a had no effect on the activity of MMP-2 ( The data of MMP-2 were 55.13 ± 0.66, 55.67 ± 0.43, 55.49 ± 0.20 and 55.91 ± 0.37 in groups A, B, C and D, F = 2.73, P = 0.079 )
Kular et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2, MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced MMP-9 expression through ß1 integrin engagement ... In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2 , MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced MMP-9 expression through ß1 integrin engagement
Liu et al., Journal of neuroinflammation 2012 (Pain) : Inhibition of MMP-9/MMP-2 suppressed CCI induced mechanical allodynia and concomitant TNF-a and IL-17A expression in nerves
Yamada et al., Biochem Pharmacol 2013 : The expression of MMP-1, MMP-3 , and MMP-9 increased in the presence of TNF-a , and the addition of infliximab reversed the increase ... Furthermore, infliximab effectively attenuated the TNF-a induced increases in MMP expression in cells that make up the BAB
Ishibashi et al., Atherosclerosis 2013 (Plaque, Atherosclerotic) : Consistent with the in vivo data, TLR3 deficiency suppressed MMP-2 activity induced by TNF-a or polyinosine-polycytidylic acid in macrophages from Apoe ( -/- ) Npc1 ( -/- ) mice
Cornelius et al., J Invest Dermatol 1995 (Neovascularization, Pathologic) : Northern hybridization assays showed pretranslational control of PMA-, basic fibroblast growth factor-, and TNF-alpha induced MMP expression
Panagakos et al., Inflammation 1995 (Osteosarcoma) : The presence of TNF-alpha suppresses maturation induced transcription of MMP-2 , enhances TIMP-1 transcription, but has little effect on MMP-9 mRNA levels
Gearing et al., J Leukoc Biol 1995 : MMP inhibitors prevent the rise in blood levels of TNF after endotoxin administration in rats and are effective in animal models of inflammatory disease such as adjuvant arthritis
Kalebic et al., Biochem Biophys Res Commun 1994 : The expression of gelatinase A in HIV infected cells was selectively increased by tumor necrosis factor ( TNF alpha ) while the expression of gelatinase B was not affected
Rawdanowicz et al., J Clin Endocrinol Metab 1994 : Both interleukin-1 alpha and tumor necrosis factor-alpha stimulated the secretion of MMP-1, MMP-3 , and MMP-9, but not MMP-2, from the cells in a concentration dependent manner
Ries et al., Blood 1994 (Leukemia, Promyelocytic, Acute) : Thus, MMP-9 secretion may be regulated by TNF-alpha not only in a paracrine but also in an autocrine fashion
Hanemaaijer et al., Biochem J 1993 : On the other hand, MMP-2 and TIMP-2 were not affected or were affected in a variable way by TNF alpha and/or phorbol ester, suggesting a dissimilar regulation of these proteins
Kubota et al., Cancer Lett 1996 (Leukemia, Myeloid, Acute...) : TNF ( 0.1-30 ng/ml ) significantly stimulated 92 kDa gelatinase secretion in a dose dependent manner, but did not significantly stimulate 72 kDa gelatinase secretion
Migita et al., Immunology 1996 (Arthritis, Rheumatoid) : Although MMP-2 is constitutively secreted by synovial fibroblasts as a pro-enzyme, stimulation of fibroblasts by TNF-alpha induced secretion of MMP-2 in an active form ... In support of this result, TNF-alpha stimulation induced membrane-type matrix metalloproteinase ( MT-MMP ), a newly identified MMP-2-specific activator on synovial fibroblasts ... Cycloheximide analysis demonstrated that protein synthesis may be required for TNF-alpha mediated MT-MMP expression on synovial fibroblasts ... Our results suggest that TNF-alpha induces MMP-2 activation in part by up-regulating MT-MMP expression, thus representing a new mechanism for cytokine mediated articular destruction in rheumatoid arthritis ( RA )
Wu et al., J Cell Physiol 1997 (Sjogren's Syndrome) : This study examined the role of IFN-gamma and ( + ) TNF-alpha in the regulation of the matrix metalloproteinases, MMP-2 ( 72 kD gelatinase A ) and MMP-9 ( 92 kD gelatinase B )
Pender et al., J Immunol 1998 : Recombinant TNF-alpha and IL-1beta added directly to mucosal mesenchymal cell lines also caused an increase in MMP production, but only the former was inhibited by the TNFR-IgG
Uitto et al., Am J Pathol 1998 (Gingivitis...) : In these cells, MMP-13 expression at the mRNA and protein level was potently enhanced ( up to sixfold ) by tumor necrosis factor-alpha , transforming growth factor-beta(1), and transforming growth factor-alpha and by keratinocyte growth factor in the presence of heparin
Mentzel et al., Clin Exp Rheumatol 1998 (Arthritis, Reactive) : TNF-alpha increased the total MMP activity released
Knittel et al., J Hepatol 1999 : In general, TNF-alpha stimulated both MMP and TIMP expression of hepatic stellate cells, while TGF-beta1 induced TIMP expression only
Wassenaar et al., Clin Exp Immunol 1999 : This down-regulatory effect of CD40 engagement on MMP-1 and MMP-3 production by gingival fibroblasts was also present when MMP production was up-regulated by IL-1beta and TNF-alpha or down-regulated by IFN-gamma