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FOS — MAP3K1

Text-mined interactions from Literome

Minet et al., Exp Cell Res 2001 : We also observed that AP-1 transcriptional activity is inhibited by a MEKK1 dominant negative mutant
Yu et al., Mol Pharmacol 2001 : Interestingly, resveratrol had little effect on the induction of AP-1 reporter gene by active Raf-1, MEKK1 , or MKK6, suggesting that it inhibited MAPK pathways by targeting the signaling molecules upstream of Raf-1 or MEKK1
Jahn et al., J Biol Chem 2001 : The inhibitory activity of Grb4 is specific for c-jun/c-fos regulated promoter elements and is located downstream of MEKK1 and JNK because co-expression of Grb4 resulted in down-regulation of MEKK1 induced AP-1 activity without affecting JNK activity
Christerson et al., J Cell Physiol 2002 : The reduced activation of AP-1 is dependent on the association of MEKK1 with p115 Rho GAP, because deletion of the Rho GAP SH3 domain, which abrogates their interaction, restores the stimulatory effect of MEKK1 on AP-1 activity
O'Reilly et al., Biochem Biophys Res Commun 2003 : Furthermore full length and C-terminal A20 showed similar regulatory effects on MEKK-1 activation of NF-kappa B and AP-1 and induction of IL-8
Rangaswami et al., Oncol Rep 2007 (Lung Neoplasms...) : OPN triggers NIK- and MEKK1 dependent AP-1 activation whereas NIK dependent AP-1 activation is independent of JNK1 that leads to pro-MMP-9 activation
Das et al., Mol Cell Biochem 2010 : Furthermore, transfection of kinase-dead MEKK1 , an initiating kinase of the JNK pathway inhibited Trx mediated AP-1 transactivation and DNA binding, suggesting that MEKK1 may mediate Trx induced AP-1 activation ... In contrast, wild-type MEKK1 overexpression did not inhibit Trx mediated AP-1 activation
Jin et al., Dev Biol 2013 : Second, MAP3K1 potentiated AP-2a expression and SRF and AP-1 activity, but its target genes were enriched for binding motifs of AP-2a and SRF, and not AP-1, suggesting the existence of novel MAP3K1-AP-2a/SRF modules in gene regulation ... Second, MAP3K1 potentiated AP-2a expression and SRF and AP-1 activity, but its target genes were enriched for binding motifs of AP-2a and SRF, and not AP-1, suggesting the existence of novel MAP3K1-AP-2a/SRF modules in gene regulation