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IFNG — MAA

Text-mined interactions from Literome

Tsujisaki et al., J Immunol 1987 : The effect of recombinant immune interferon ( IFN-gamma ) on the expression and shedding of HLA antigens and of melanoma associated antigens (MAA) by epidermal melanocytes was investigated by using serologic and immunochemical techniques ... IFN-gamma enhances the expression and/or shedding of HLA class I antigens and of the cytoplasmic MAA defined by monoclonal antibody ( MoAb ) 465.12S and induces a slight reduction in the expression of the high m.w. melanoma associated antigen ( HMW-MAA ) ... Contrary to previous information in the literature, the effect is not restricted to HLA class II antigens, since IFN-gamma also induces the expression of the 96-kDa MAA recognized by MoAb CL203 ... The effect of IFN-gamma on HLA class II antigens and 96-kDa MAA is dose and time dependent and is specific, because recombinant leukocyte interferon affects the expression of neither type of antigen
Matsui et al., J Immunol 1987 (Carcinoma...) : The effect of IFN-gamma on the 96,000 MAA is dose- and time dependent, reversible, and blocked by inhibitors of RNA and protein synthesis ... Furthermore, the effect of IFN-gamma on the induction of the 96,000 MAA appears to be specific, inasmuch as IFN-alpha and IFN-beta do not induce the expression of the 96,000 MAA
Giacomini et al., J Immunol 1985 (Melanoma) : IFN-gamma increased the synthesis and shedding of the cytoplasmic MAA, but reduced the synthesis and cell surface expression of the HMW-MAA and of the 100K MAA ... The effects of IFN-gamma on the cytoplasmic MAA are similar to those of leukocyte and fibroblast interferons, whereas those on the membrane bound MAA are significantly different