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ANGPT2 — MMP9

Text-mined interactions from Literome

Etoh et al., Cancer Res 2001 (Neovascularization, Pathologic...) : MMP-1, MMP-9 , and urokinase-type plasminogen activator in ECs were strongly up-regulated by Ang-2 in the presence of VEGF in vitro
Das et al., Lab Invest 2003 : The stimulation of cultured retinal endothelial cells with Ang-1 and -2 resulted in the increased expression of matrix metalloproteinase (MMP)-9
Yoshiji et al., Gut 2005 (Liver Neoplasms, Experimental...) : Ang-2 plus VEGF overexpression significantly increased the activities of matrix metalloproteinase (MMP)-2 and MMP-9 in the tumour
Nazari et al., J Med Invest 2007 (MAP Kinase Signaling System) : We next tested the effect of broad-spectrum matrix metalloproteinase ( MMP ) inhibitor ( GM6001 ) on Ang II-inhibition of insulin signaling pathway
Huang et al., Dig Dis Sci 2008 (Stomach Neoplasms) : In this study, we investigated the expression of angiotensin II type1 receptor (AT1R) in gastric cancer and the effects of Ang II on the expression of MMP2 and MMP9 in the human gastric cancer cell line MKN-28 cells ... Furthermore, Ang II promoted the expression of MMP2 and MMP9 in MKN-28 cells, and the stimulatory effects of Ang II could be blocked by AT1R antagonist
Zack et al., Atherosclerosis 2011 (Aortic Aneurysm, Abdominal...) : Ang II induction of cyclooxygenase-2, interleukin-6, matrix metalloproteinase (MMP)-2 , MMP-13 and MMP-14 was reduced significantly in GX DKO mice compared to apoE ( -/- ) mice
Martinez-Lemus et al., Am J Physiol Heart Circ Physiol 2011 (Disease Models, Animal...) : Inhibition of MMP activation ( with GM-6001 ) or ROS production ( with apocynin or tempol ) prevented the NE + ANG II-induced inward remodeling
Valente et al., J Mol Cell Cardiol 2012 (Cardiomegaly...) : Further, Ang-II induced IKK/p65 and JNK/c-Jun phosphorylation, NF-?B and AP-1 activation, and IL-18 and MMP-9 expression were also markedly attenuated in CIKS-null mice
Qiu et al., Pharmazie 2012 : With a lentiviral shRNA specifically targeting OPN and transwell migration assay, we find that blockade of OPN with shRNA inhibits Ang-II induced MMP9 upregulation and VSMCs migration
Liu et al., Free Radic Biol Med 2013 (Fibrosis...) : In in vitro experiments performed in neonatal rat cardiac fibroblasts, leonurine ( 10-20µM ) pretreatment attenuated Ang II-induced activation of extracellular signal regulated kinase 1/2, production of intracellular reactive oxygen species ( ROS ), expression and activity of matrix metalloproteinase (MMP)-2/9 , and expression of a-smooth muscle actin and types I and III collagen