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LEP — TYR

Text-mined interactions from Literome

Li et al., Proc Natl Acad Sci U S A 1999 (Obesity) : After cotransfection of Ob-Rb, Janus kinase 2 (JAK2), and SHP-2 into 293T cells, leptin results in direct binding of SHP-2 to the phosphorylated Tyr 985
O'Rourke et al., Biochem J 2002 : While the MEK-1 [ mitogen activated protein kinase ( MAP kinase ) /extracellular-signal related kinase ( ERK ) kinase-1 ] inhibitor PD98059 [ ( 2-amino-3'-methoxyphenyl ) oxanaphthalen-4-one ] had no effect on leptin stimulated phosphorylation of STAT3 Tyr705 , it greatly attenuated leptin 's effects on STAT3 Ser727 phosphorylation
Sánchez-Margalet et al., Clin Exp Immunol 2003 (Autoimmune Diseases...) : Leptin also stimulates Tyr-phosphorylation of the RNA binding protein Sam68 mediating the dissociation from RNA
Myers et al., Annu Rev Physiol 2008 (Obesity) : A number of mechanisms, including the leptin stimulated phosphorylation of Tyr ( 985 ) on LRb and the suppressor of cytokine signaling 3, attenuate leptin signaling and promote a cellular leptin resistance in obesity