Gene interactions and pathways from curated databases and text-mining

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IGFBP2 — RELA

Text-mined interactions from Literome

Eichten et al., Virology 2004 : Expression of two insulin-like growth factor-1 binding proteins, IGFBP-2 and -5, is increased presumably in response to enhanced NF-kappaB activity in HPV-16 E7-expressing serum starved cells
Cazals et al., Biochim Biophys Acta 1999 (Hyperoxia) : Role for NF-kappa B in mediating the effects of hyperoxia on IGF binding protein 2 promoter activity in lung alveolar epithelial cells ... From examination of the IGFBP-2 gene promoter sequence which revealed the presence of four potential binding sites for transcription factors of the NF-kappa B/Rel family, we hypothesized that NF-kappa B might be involved in the transcriptional activation of IGFBP-2 in oxidant exposed cells ... Data reported herein demonstrated that NF-kappa B activated IGFBP-2 promoter in transient transfection assays, and that exposure of cells to hyperoxia was associated with accumulation of the active form of NF-kappa B