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IL8 — PF4

Pathways - manually collected, often from reviews:

• Reactome Reaction: PF4 → IL8 (reaction) Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994

Text-mined interactions from Literome

Engstad et al., Thromb Haemost 1999 : Upon addition of 50 microg/ml of the carboxyterminal peptide of platelet factor 4 ( PF4 ( 58-70 ) ) to whole blood, LPS stimulated IL-8 levels were increased with 115 %, whereas in mononuclear cells, 20 microg/ml PF4 ( 58-70 ) enhanced IL-8 production with 40 %
Martí et al., J Leukoc Biol 2002 : Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8 ... Stimulation of NK cells through the Fc receptor for immunoglobulin G-IIIA was found to synergistically increase the effect of PF4 on IL-8 production but did not affect IL-2 related activities such as cytotoxic activity and proliferation
Leonard et al., J Leukoc Biol 1991 : The binding of fluoresceinated NAP-1 to neutrophils was inhibited by unlabeled NAP-1 or NAP-2 but not by PF-4 or PF-4 ( 59-70 )
Thomas et al., J Immunol 1994 : Rabbit neutrophils mobilized intracellular Ca2+ in response to IL-8 and NAP-2 but not to GRO or PF4